导读：与单药治疗相比，PD-1阻断和IL-2联合治疗显著提高抗肿瘤疗效。可是，联合治疗产生协同效应的潜在机制仍不清楚。近日，武汉大学研究人员在知名期刊《Cell Research》上发表了题为“PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to ...
近日,武汉大学研究人员在知名期刊《Cell Research》上发表了题为“PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity”的研...
近日,武汉大学研究人员在知名期刊《Cell Research》上发表了题为“PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity”的研究论文,该研究中,研究人员发现PD-1连接导致BATF依赖的膜相关E3泛素连接酶MARCH5的...
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunityCombination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The underlying mechanisms ...
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-L1) for a subset of cancer patients. PD-1 signaling negatively regulates T cell-mediat...
1. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow |Nat Commun(IF = 16.6, 2022) 研究背景 目前研究表明,在多微生物脓毒症、病毒和寄生虫感染条件下可以诱导中性粒细胞表达PD-L1来抑制宿主免疫。然而,PD-L1在中性粒细胞介导的抗真菌免疫中的作用仍不清楚。
PD-1 negatively regulates TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is ...
Article Open access 20 April 2021 PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity Article Open access 06 November 2023 Introduction Immune checkpoint inhibitors targeting PD-1/PD-L1 or CTLA-...
1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-...
1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-...