PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunityCell signallingTumour immunologyCombination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The...
导读：与单药治疗相比，PD-1阻断和IL-2联合治疗显著提高抗肿瘤疗效。可是，联合治疗产生协同效应的潜在机制仍不清楚。近日，武汉大学研究人员在知名期刊《Cell Research》上发表了题为“PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to ...
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-L1) for a subset of cancer patients. PD-1 signaling negatively regulates T cell-mediat...
PD-1通过结合其两个配体PD-L1和PD-L2来发出信号，PD-L7和PD-L1都是B1家族的成员。配体结合后，PD-1信号传导抑制T细胞活化，导致增殖减少，细胞因子产生和T细胞死亡。此外，已知PD-1在小鼠外周耐受和预防自身免疫性疾病中起关键作用，因为PD-1基因敲除动物表现出扩张型心肌病，脾肿大和外周耐受性丧失。诱导PD-L8...
At homeostasis, blockade of the PD-1 pathway results in enhanced eTreg cell activity, whereas during infection with Toxoplasma gondii, early interferon-γ upregulates myeloid cell expression of PD-L1 associated with reduced Treg cell populations. In infected mice, blockade of PD-L1, complete ...
1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-...
1 is a natural phenomenon that occurs following T cell activation, resulting in beneficial effects in protecting peripheral tolerance and preventing autoimmune diseases. Tumors escape host immune surveillance by expressing PD-L1, which negatively regulates immune responses through its interaction with PD-1...
Furthermore, IFNAR blockade caused an upregulation of PD-L1 on circulating neutrophils, suggesting that IFN-I signaling negatively regulates PD-L1 expression on neutrophils. Although we demonstrate that IFNAR blockade can enhance antitumor T cell activity, it has been well established that IFN-I ...
(TNF-α), thus inhibiting the antitumor immune response [47,48]. Although there are limited studies using PD-1+B cells as the target cells for primary PD-1 blockade therapy, theoretical studies have shown that blocking PD-1 signaling in B cells can restore their normal immune function and ...
Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling Shengqi Wang, Jing Li, Shicui Hong, Neng Wang, Shang Xu, Bowen Yang, Yifeng Zheng, Juping Zhang, Bo Pan, Yudie Hu & Zhiyu Wang...