目的:探讨长链非编码RNA PCBP1-AS1(LncRNA PCBP1-AS1)对口腔鳞状细胞癌(OSCC)细胞增殖,侵袭及凋亡的影响及其可能机制.方法:采用实时荧光定量聚合酶链反应检测OSCC细胞中PCBP1-AS1的表达水平;采用Lipofectamine 2000将pcDNA-PCBP1-AS1及pcDNA-control转染入口腔鳞癌CAL-27细胞;甲基噻唑基四唑实验检测CAL-27细胞的增殖...
PCBP1-AS1可通过下调miR-196a的表达从而抑制口腔鳞癌细胞增殖、迁移及侵袭。 关键词: 口腔鳞癌;增殖;迁移;侵袭 ABSTRACT The purpose of this study was to investigate the effect of LncRNA PCBP1-AS1 on the proliferation, migration and invasion of oral squamous carcinoma cells and its targeted regulation...
In this study, we investigated the roles and action mechanism of lncRNA poly(rC)-binding protein 1-antisense RNA 1 (PCBP1-AS1) in cerebral ischemia/reperfusion (I/R) injury. Methods. We used a middle cerebral artery occlusion (MCAO) model in vivo and an oxygen-glucose deprivation/...
从而筛选出细胞系用于构建PCBP1-AS1过表达和干扰细胞株.利用克隆形成实验,EDU,CCK8实验研究发现PCBP1-AS1可以促进肝癌细胞的增殖,细胞划痕实验和细胞迁移,侵袭实验发现PCBP1-AS1促进肝癌细胞侵袭和迁移.我们建立了裸鼠皮下异种移植模型和尾静脉异种移植模型进行动物实验,结果表明PCBP1-AS1过表达促进肝癌细胞的增殖和侵袭...
研究发现PCBP1-AS1在口腔鳞癌组织中低表达, 而miR-196a表达上调;转染pcDNA-PCBP1-AS1或转染anti-miR-196a均可抑制细胞增殖,迁移及侵袭, 并可诱导细胞周期停滞于G0-G1期;PCBP1-AS1可靶向调控miR-196a;miR-196a过表达可逆转PCBP1-AS1对细胞生物学行为的作用.PCBP1-AS1可通过下调miR-196a的表达从而抑制口腔...
PCBP1-AS1可通过下调miR-196a的表达从而抑制口腔鳞癌细胞增殖、迁移及侵袭。 关键词: 口腔鳞癌;增殖;迁移;侵袭 ABSTRACT The purpose of this study was to investigate the effect of LncRNA PCBP1-AS1 on the proliferation, migration and invasion of oral squamous carcinoma cells and its targeted regulation...
LncRNA PCBP1-AS1-mediated AR/AR-V7 deubiquitination enhances prostate cancer enzalutamide resistancedoi:10.1038/s41419-021-04144-2Boya ZhangMingpeng ZhangChunyi ShenYao WeitaoNature Publishing Group
The refractory of castration-resistant prostate cancer (CRPC) is mainly reflected in drug resistance. The current research on the resistance mechanism of CRPC is still in its infancy. In this study, we revealed for the first time the key role of LncRNA PCBP1-AS1 in CRPC drug resistance. ...
LncRNA EIF1AX-AS1 Promotes Endometrial Cancer Cell Apoptosis via Interacting With PCBP1 to Facilitate EIF1AX mRNA Destabilizationdoi:10.2139/ssrn.3937537long non-coding RNAEIF1AXIRESendometriumRNA binding proteinBackground: Endometrial cancer (EC) is the most common malignant tumor of the female ...