CTBP1-AS2相对表达量.分别用1,2,4和8μg·mL-1替莫唑胺诱导胶质瘤U251细胞,构建U251/替莫唑胺耐药(U251/TR)细胞系;用慢病毒转染构建稳定干扰CTBP1-AS2的U251/TR(U251/TR-CTBP1-AS2)细胞系.检测U251细胞,U251/TR细胞系,U251/TR-CTBP1-AS2细胞系的替莫唑胺IC50值.RT-PCR法检测细胞CTBP1-AS2表达...
干扰lncRNA CTBP1-AS2表达可通过促进miR -205-5p 表达抑制细胞凋亡及炎症反应，从而减轻IL -1β诱导的大鼠髓核细胞损伤。［关键词］ 大鼠髓核细胞；lncRNA CTBP1-AS2；miR -205-5p ；凋亡；炎症 Study on molecular mechanism of lncRNA CTBP1-AS2 influencing nucleus pulposus cell apoptosis and inflammation ...
First, we discovered the low expression of CTBP1-AS2 in normal heart tissues in GETx database. Then, we established cardiomyocyte hypertrophy models on mice and cardiomyocytes through transverse aortic constriction surgery and Ang II treatment. We revealed the up-regulation of CTBP1-AS2 and TLR4 ...
Cholangiocarcinoma (CCA) is a serious malignancy originating from the bile ducts and the second most common primary liver cancer. Long non-coding RNA (lncRNA) is a functional lncRNA that plays an important role in human cancers. However, the role and underlying mechanisms of CTBP1-AS2 in CCA...
CELL migrationTherefore, CTBP1-AS2 may sponge miR-216a to upregulate PTEN, thereby suppressing endometrial cancer cell invasion and migration.doi:10.1186/s13048-020-00639-2Wang, Qing-an-ziYang, YongxiuLiang, XiaoleiBioMed CentralJournal of Ovarian Research...
鼻咽癌组织中 LncRNA CTBP1-AS2 和 miR-140-5p 水平表达与 放疗疗效及预后的关系研究doi:10.3969/j.issn.1671-7414.2024.02.005顾刘雷顾培金广浩田野陶勇Journal of Modern Laboratory Medicine
Functionally, CTBP1-AS2 knockdown inhibited tumor cell growth and invasion in vitro. Mechanistically, CTBP1-AS2 may competitively bind with miR-381-3p and then regulate ID1 to act as a tumor-promoter in breast cancer. Collectively, these results reveal the potential role of lncRNA CTBP1-AS2 ...
CCK-8 analysis showed that CTBP1-AS2 and cyclin D1 overexpression promoted the proliferation of HCC cells. MiR-623 overexpression played an opposite role and reduced the effects of CTBP1-AS2 and cyclin D1 overexpression. Therefore, CTBP1-AS2 promotes cell proliferation in HCC by regulating miR-...
As revealed by the clinical assays, high CTBP1-AS2 expression usually related to lymph node metastasis, clinical stage and weaker prognosis specific to HCC patients. Functionally, CTBP1-AS2 knockdown suppressed HCC cells in terms of the proliferation, migration, invasion, chemotherapy resistance as ...
CTBP1AS2 inhibits proliferation and induces autophagy in oxLDLstimulated vascular smooth muscle cells by regulating miR1955p/ATG14.doi:10.3892/IJMM.2020.4624Yang WangChengXin ZhangShengLin GeWenHui GongSpandidos Publications