The refractory of castration-resistant prostate cancer (CRPC) is mainly reflected in drug resistance. The current research on the resistance mechanism of CRPC is still in its infancy. In this study, we revealed for the first time the key role of LncRNA PCBP1-AS1 in CRPC drug resistance. ...
Together, our findings elucidate that GAS6-AS1 directly binds to PCBP1, enhancing MCM3 expression and thereby promoting 5-FU resistance. GAS6-AS1 may serve as a robust biomarker and potential therapeutic target for combination therapy in CRC....
such as lymphatic metastasis, tumor size, tumor stage, OS and DFS. Thus, MNX1-AS1 can be used as a diagnostic and prognostic biomarker or even a therapeutic prognostic target. This article reviews its function, molecular mechanism and clinical prognosis in various malignancies....
PAX8-AS1-2, PCA3-1, PCA3-2, PCAT-1, PCAT18, PCAT29, PCAT6-1, PCAT6-2, PCBP2-OT1, PCGEM1, PGM5-AS1-1, PGM5-AS1-2, PICSAR, PINC, POU6F2-AS2, PRNCR1, PSF inhibiting RNA, PTCSC1, PTCSC3, PTENP1, RGMB-AS1, RMEL3, RUNX1-IT1, SAMMSON , SBF2-AS1, SCHLAP1, SNH...
For instance, FUS interacts with lncRNA CTBP1-AS2 to stabilize TLR4 in cardiomyocyte hypertrophy [39]. FUS could also bind to lncRNA DLX6-AS1 to regulate MAP4K1, thus promoting cell proliferation, migration and EMT of gastric cancer [40]. In this study, we demonstrated that KCNQ1OT1 was...
目的 探究LncRNA MEG3在口腔鳞状细胞癌 (oral squamous cell carcinoma, OSCC) 组织和细胞中的表达水平及对OSCC细胞增殖、侵袭和凋亡的影响.方法 qRT-PCR法检测OSCC患者口腔粘膜组织、肿瘤组织及Tca8113细胞系中LncRNA MEG3的表达水平.构建pcDNA3.1-MEG3重组质粒转染Tca8113细胞, 分为3组:转染过表达pcDNA3.1...
目的:探讨长链非编码RNA PCBP1-AS1(LncRNA PCBP1-AS1)对口腔鳞状细胞癌(OSCC)细胞增殖,侵袭及凋亡的影响及其可能机制.方法:采用实时荧光定量聚合酶链反应检测OSCC细胞中PCBP1-AS1的表达水平;采用Lipofectamine 2000将pcDNA-PCBP1-AS1及pcDNA-control转染入口腔鳞癌CAL-27细胞;甲基噻唑基四唑实验检测CAL-27细胞的增殖...
LncRNA PCBP1-AS1-mediated AR/AR-V7 deubiquitination enhances prostate cancer enzalutamide resistancedoi:10.1038/s41419-021-04144-2Boya ZhangMingpeng ZhangChunyi ShenYao WeitaoNature Publishing Group
LncRNA EIF1AX-AS1 Promotes Endometrial Cancer Cell Apoptosis via Interacting With PCBP1 to Facilitate EIF1AX mRNA Destabilizationdoi:10.2139/ssrn.3937537long non-coding RNAEIF1AXIRESendometriumRNA binding proteinBackground: Endometrial cancer (EC) is the most common malignant tumor of the female ...
Several hub-lncRNAs including C14orf169, YLPM1, TTTY15, and PCBP1-AS1 were screened. The sub-pathways regulated by these lncRNAs were identified, and functions were predicted.doi:info:doi/10.3892/etm.2018.6089Tang, GongjieZhang, TaoWang, Xinbo...