Qinghai H5N1 Mutation PB2 E627K in All Human Isolates - July 9, 2005Genetic Tracking & Scientfic Analysis of Pandemic Influenza & Other Diseases
The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41years. The virus has spread efficiently to both ... BW Jagger,MJ Memoli,ZM Sheng,... -...
Polymerase complexes possessing PB2-E627K displayed 16.1-fold higher viral polymerase activity when compared to the wild-type virus, which may account for enhanced virulence of this virus. The other two substitutions (HA-N313D and HA-N496S) enhanced binding to both 伪2,3-linked and 伪2,6-...
PB2 E627KHighly pathogenic avian influenza (HPAI) viruses pose a potential human health threat as they can be transmitted directly from infected poultry to humans. During a large outbreak of HPAI H7N7 virus among poultry in The Netherlands in 2003, bird to human transmission was confirmed in ...
PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Virology, 2014, 468-470C: 207-213Cheng K, Yu Z, Chai H, et al. PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a ...
PB2-292I coupled with 627K also enhances viral transcription and replication in cells, whereas PB2-292I alone did not show the same effect in the H7N9 virus. However, PB2-740A only had a limited prevalence in 2013, and the change from D to A in PB2-740A may have a negative ...
Qi Wen-bao; Tian Jin; Su Shuo;.Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by comparative proteomics.Pro- teomics.2015.1512-1524Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by ...