Qi Wen-bao; Tian Jin; Su Shuo;.Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by comparative proteomics.Pro- teomics.2015.1512-1524Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by ...
Qinghai H5N1 Mutation PB2 E627K in All Human Isolates - July 9, 2005Genetic Tracking & Scientfic Analysis of Pandemic Influenza & Other Diseases
In ferrets, the mouse-adapted virus induced more severe disease, replicated to higher titers in the lower respiratory tract and spread more efficiently to systemic organs compared with the parental virus.In vitro, the PB2 E627K mutation had a promoting effect on virus propagation in mammalian, ...
H7N9Adaptive mutationCharacterization of host adaptation markers among human isolates is important for recognizing the potential for cross-species transmission in avian influenza A viruses. Here, we studied two new potential adaptive mutations, V292I and D740A, in the PB2 protein that were identified...