Cancer cells lack a tumor microenvironment (TME) and genetic diversity, whereas PDTXs are expensive and have a time-consuming preparation protocol. Therefore, alternative research models are warranted. Patient-derived organoids (PDOs) are a promising in vitro model. They m...
Moreover, patient-derived tumour organoids (PDOs) have emerged as a promising experimental model for personalised medicine [6, 10, 11], as they have shown high phenotypic and genotypic similarity [7, 12] as well as similar treatment response [7, 12, 13] compared to the original patient ...
Patient-derived Organoids as a Tool for Advancing Precision Immuno-oncology The application of three-dimensional (3D) spheroids or organoids in drug testing and precision medicine has led to significant advancements in how cancer a... YT Xin,TT Ong,KH Chow - 《World Scientific Annual Review of...
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively revolutionized three-dimensional cell culture in oncology. PDTO can be grown from patient tumor samples with high efficiency and faithfully recapitulates th...
neovascularization, distant metastasis, and investigating the side effects of drugs. Interestingly, several research groups have demonstrated that patient-derived organoids (PDOs) and PDXs could be interconverted with high efficiency [95,96]. In light of this result, we can speculate that PDO may ...
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer Peter D. Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E. Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic & ...
Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of primary breast tumors. Despite their promise, the rate of successful PDX engraftment is various in ...
Patient-derived 3D cell cultures (human organoids) have become a valuable tool in the study of human diseases, complementing and in some cases replacing animal studies [11,12,13]. In oncology, 3D cell cultures have been successfully used to study tumor development and progression and to test ...
Recent years have seen the development of patient-derived organoid models as a pre-clinical model, but these involve the manipulation and mechanical or enzymatic digestion of human tumour tissue and are often derived from a single cell type (tumour cells)13,14 which does not fully mimic human ...
CircRAD23B promotes proliferation and carboplatin resistance in ovarian cancer cell lines and organoids Hui Wang Yashuang Zhang Wenjun Cheng Cancer Cell International(2024) Organoid as a promising tool for primary liver cancer research: a comprehensive review ...