organoids of patients can be generated from the tissues obtained from surgery or biopsy to construct biobanks of patient-derived organoids (PDOs). PDOs have been shown to preserve their clinical markers, histomorphology, driver mutations, and even molecular and metabolite heterogeneity, which assure...
M. Bershteyn, H. Retallack, M. A. Mostajo Radji and A. Pollen for their scientific discussions and thoughtful input. The authors are very grateful to T. Nowakowski for his help with the illustrations. This work was supported by funding from the US National Institutes of Health R35NS097305...
However, CRC still faces challenges in clinical treatment, most likely due to the lack of suitable models. Numerous studies have demonstrated that CRC organoids retain the histopathological structure of their parent tumors, making them ideal models for studying cancer initiation, tumor invasion, and ...
While human and murine models have been the mainstay of organoid research, their application in animal models is expanding rapidly. Figure6illustrates the time lag between the establishment of species-specific organoids and their application in infectious disease research. Human and murine organoids, ...
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Currently, increasing emerging technologies such as single-cell sequencing have been widely applied in medical research [31]. Taking advantage of them to study brain organoids will help us to explore these models more deeply and achieve a better understanding of their practicality [32]. After 1 ...
Correction: Patient-derived organoids for precision oncology: a platform to facilitate clinical decision makingdoi:10.1186/s12885-023-11269-4DECISION makingORGANOIDSONCOLOGYCALCIUM ionsOVARIAN cancerTraces shown are typical phenotypic responses including unaffected regular Ca 2 flux p...
Organoids are fast becoming cutting-edge tools of modern life sciences. The idea is to use stem cells to build miniature tissues and organs that accurately resemble and behave like their real counterparts.
For example, ferrets are a favorable model for studying transmission of influenza viruses, owing to the high histological and anatomical similarity of their respiratory tracts to those of human15. However, inherent differences between host species limit clinical translatability of findings from animal ...
by Tamar Evron-Levy 1, Michal Caspi 1, Amnon Wittenstein 1, Yamit Shorer-Arbel 1, Olga Shomron 2, Koret Hirschberg 2, Revital Kariv 3,†and Rina Rosin-Arbesfeld 1,*,† 1 Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69...