A brief history of organoids. Am J Physiol Cell Physiol 319: C151-C165, 2020. First published May 27, 2020; doi: 10.1152/ajpcell.00120.2020.In vitro cell cultures are crucial research tools for modeling human development and diseases. Although the conventional mono-layer cell cultures have ...
Programmable Human Organoids via Genetic Design and Engineering 53:05 Large Systems of Interacting Particles and their Applications in Optimization 51:48 High-Order Accuracy Computation of Coupling Functions for Strongly Coupled Oscil 44:34 Footnotes to Turing (1952)_ Some Modern Challenges in Patt...
Although organoids hold great promise for the field of plastic surgery, technical challenges in creating vascularized, multilineage organoids must be overcome to allow for the integration of this technology in clinical practice. This review provides a brief history of the organoid, highlights its ...
aBrief scheme of major procedures involved in the generation and quality control of E-islets and the safety/effectiveness evaluations of E-islet transplantation.b–dE-islets reverse hyperglycemia in STZ-induced diabetic immunocompromised mice. Schematic illustration of kidney capsule transplantation of E-i...
9125 Accesses 1 Citations 622 Altmetric Metrics details An Author Correction to this article was published on 27 February 2024This article has been updatedAbstract Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely ...
However, the ACT method has some limitations, such as the risk of rejection in allogeneic engrafts. Accordingly, numerous efforts are being made to eliminate or minimize this and other complications. In the present review, we have developed a guide to breast cancer (BC) therapy from ...
Cell culture models also support the involvement of HSV-1 in AD.In vitro studies by Cairns et al., Qiao et al. and D’Aiuto et al. have shown that HSV-1 can induce AD-like pathology in human induced pluripotent stem cell (hiPSC) -derived neural cultures and 3D organoids[145,146,147...
Parkinson’s disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates containing misfolded α-synuclein (α-syn) in a phosphorylated form. The lack of effective m
2). In brief, the program receives cell source, volumetric cell density within the device, and a description of the device’s geometry, generates the device in silico treating islets or SC-βs as randomly distributed spheres with diameters sampled from their corresponding size distributions (...
Due to the limited clinical history of our cohort, we focused on patient information such as age, gender, racial, and ethnic background, and gene expression data derived from RNA-seq. These attributes have shown their effectiveness in the development of genotype–phenotype studies34. In the ...