As evidenced for HSV-1, organoid-based cervical models may serve to study sexually transmitted infections. Starting from Pap brush material, a small biobank of tumoroids derived from affected individuals was established that retained the causative human papillomavirus (HPV) genomes. One of these ...
Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell Shoichi Ukai Ririno Honma Wataru Yasui Article12 Oct 2020Oncogene Establishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organo...
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited...
Among these patients, three were further pursued to have the organoids derived from their tumor tissues tested for the sensitivity to different therapeutic drugs in parallel to their clinical care. Our results showed that the therapeutic effects observed by the organoid models were consistent to the...
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurat
Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human...
and CTC-derived organoid models for CTCs analyses. We also reviewed the progress of scientific research in studying cfDNA/ctDNA and EVs in patient-derived models. At the same time, we identified essential efforts to make these models more applicable for research on the liquid biopsy analytes so...
Here, we summarise recent advancements in PDOs from the perspective of cancer biology and clinical applications, focusing on the current challenges and opportunities of reconstructing and standardising more sophisticated PDO models. Statement of Significance Patient-derived tumour organoids (PDOs), three...
Patient-derived models (PDMs, particularly organoids and xenografts) are irreplaceable tools for precision medicine, from target development to lead identification, then to preclinical evaluation, and finally to clinical decision-making. So far, PDM-based proteomics has emerged to be one of the cuttin...
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer Peter D. Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E. Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic & ...