Androgen deprivation therapy (ADT) is the foundation of systemic therapy for prostate cancer. Although it is an effective cancer treatment in a variety of clinical settings, it causes accelerated loss of bone mineral density (BMD) and is associated with an increased incidence of fractures. National...
Prostate cancer is more common in the western countries, least common in Asia, and the leading cause of cancer deaths in males worldwide. Individuals who have first-degree family members with prostate cancer have double the risk of getting disease. Risk factors for prostate cancer include family...
Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, which is the study of changes in gene expression without altering the DNA sequence, has been recognized as a major driver of this disease. In the past 50 years, advancements ...
Several studies have attempted to correlate the extent of skeletal metastatic involvement, the number of bone metastases (BMTs) identified by bone scintigraphy or the distribution of BMTs (axial vs appendicular) with survival in patients with advanced prostate cancer (PC) [1, 2]. The number of ...
FG Herrera,T Tawadros,DR Berthold - 《Bone Cancer》 被引量: 0发表: 2015年 Bone Metastases of Prostatic Cancer-Chapter 37:Pathophysiology, Clinical Complications, Actual Treatment and Future Directions Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and futur...
pathophysiology of cancer pain is largely unknown, significant enhancement of glial fibrillary acidic protein (GFAP) staining in the corresponding segments of ... Medhurst,J S.,Walker,... - 《Pain》 被引量: 703发表: 2002年 Natural history and treatment of bone complications in prostate cancer....
This innermost zone contains large amounts of 17α-hydroxylase and 17,20-lyase, resulting in the production of dehydroepiandrosterone (DHEA), sulfated DHEA (DHEA-S), and androstenedione, which may have roles in the treatment of advanced prostate cancer. Aberrations in the production of these horm...
Bone is a very common site for cancer metastasis and may be the only site of metastasis in patients with breast cancer or prostate cancer. The exact incidence of bone metastasis is unknown, but it has been estimated that approximately 300,000–400,000 people in the United States die from bo...
On the pathophysiological side, PTHrP is produced by virtually all tumor types that metastasize to bone such as breast cancer, prostate cancer, lung cancer, and hematological malignancy. The complex regulation of PTHrP gene promoter is beginning to be understood in the context of activation of ...
of healthy individuals. An etiologic link between XMRV infection and human disease, however, has yet to be established. Here, we summarize existing knowledge regarding the characteristics of XMRV replication, association of XMRV with prostate cancer and CFS, and potential mechanisms of XMRV ...