This innermost zone contains large amounts of 17α-hydroxylase and 17,20-lyase, resulting in the production of dehydroepiandrosterone (DHEA), sulfated DHEA (DHEA-S), and androstenedione, which may have roles in the treatment of advanced prostate cancer. Aberrations in the production of these horm...
On the pathophysiological side, PTHrP is produced by virtually all tumor types that metastasize to bone such as breast cancer, prostate cancer, lung cancer, and hematological malignancy. The complex regulation of PTHrP gene promoter is beginning to be understood in the context of activation of ...
Relationship between upregulated estrogen receptors and expression of growth factors in cultured human, prostatic stromal cells exposed to estradiol or dihydrotestosterone. Prostate Cancer Prostatic Dis 2004; 7: 57–62. Article CAS PubMed Google Scholar Sanda MG, Beaty TH, Stutzman RE, Childs B, ...
MicroRNAs (miRNAs) are small, non-coding RNA molecules, typically ranging from 19 to 25 nucleotides in length, that function in post-transcriptional regulation and facilitate the silencing of gene expression through RNA interference [5,6]. As such, they are able to regulate various cellular proces...
FSH is another pituitary hormone and its excessively high levels in the blood are linked to atherosclerosis. For instance, menopausal women and prostate cancer patients under androgen deprivation therapy exhibit the abnormally high levels of FSH and therefore are at a high risk of developing atheroscle...
What is the relatively common autoimmune disease in which the thyroid gland produces excessive amounts of thyroxine? a. Systemic lupus erythematosis b. Myasthenia gravis c. Graves' disease d. Glomerulonephritis e. Multiple sclerosis What are the causes and symptoms...
The administration of ETAR antagonists in the receptive fields of these nociceptors has been shown to ameliorate pain-related behaviours in animals, as well as in some patients with advanced metastatic prostate cancer. The identification of tumour-associated mediators that might directly or indirectly ...
On the pathophysiological side, PTHrP is produced by virtually all tumor types that metastasize to bone such as breast cancer, prostate cancer, lung cancer, and hematological malignancy. The complex regulation of PTHrP gene promoter is beginning to be understood in the context of activation of ...
However, the condition might cause local pain and tenderness, could occasionally be the result of a serious underlying illness or a medication, or be inherited. Breast cancer in men is much less common than benign gynaecomastia, and the two conditions can usually be distinguished by a careful ...
b Histology of human mammary gland. The sample shown in this figure is from a tissue microarray developed by the Cooperative Human Tissue Network (CHTN) of the National Cancer Institute (http://www.chtn. nci.nih.gov/). Mammary gland alveoli and ducts form an extensive network of ...