Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint ...
Magnetic Resonance Imaging of the Knee. Springer-Verlag Berlin Heidelberg; 2013: 181-198. Google Scholar Berenbaum F. Osteoarthritis. B. Pathology and pathogenesis. In: Klippel JH, Stone JH, Crofford LJ, White PH, eds. Primer on the Rheumatic Diseases. New York, NY: Springer Science+...
Intra-articular treatment options for knee osteoarthritis 2019, Nature Reviews Rheumatology Interleukin-1, Tumor Necrosis Factor α, and Interleukin-17 Synergistically Up-Regulate Nitric Oxide and Prostaglandin E<inf>2</inf> Production in Explants of Human Osteoarthritic Knee Menisci 2001, Arthritis and ...
Figure 1 – The stages of osteoarthritis, as demonstrated in the knee jointRisk Factors Osteoarthritis has a multifactorial aetiology and can be primary (with no obvious cause) or secondary (due to trauma, infiltrative disease or connective tissue diseases). Risk factors for primary OA include obes...
USA; 2Department of Aging and Geriatric Research, Institute on Aging, Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA Abstract: For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted....
What is the pathophysiology of osteoarthritis?Cartilage:Cartilage is a fibrous tissue that is extremely strong and flexible, and it may take numerous shapes and fulfill many functions throughout the body. It is a solid tissue, although it is softer and more malleable than bone. Chondrocytes are ...
To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality...
Objective To elucidate the pathophysiologic links between prostaglandin E2 (PGE2) and osteoarthritis (OA) by characterizing the catabolic effects of PGE2 and its unique receptors in human adult arti...
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. Pain. 2012;153:1837–46. CAS PubMed ...
Osteoarthritis (OA) is a common condition affecting nearly 600 million people across the globe, with a significant burden of disability, especially in the later stages of the disease. For patients, OA can result in pain, stiffness, and reduced function,