Osteoarthritis of the knee affects a large population worldwide and is associated with an extremely high economic burden largely attributable to the effects of disability, comorbid disease, and the expense of treatment. Since the initiating events that result in the cartilage degradation are poorly ...
Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β. The proliferation o
We conducted a proteomic analysis of synovial fluid (SF) to identify differentially expressed proteins and analyse their correlation with osteoarthritis (OA) severity. Our primary purpose was to gain insight into the pathogenesis of OA.SF samples were acquired from 12 knee OA patients and 12 non-...
The Natural History of Bone Marrow Lesions in Community-Based Middle-Aged Women Without Clinical Knee Osteoarthritis Objective Bone marrow lesions (BML) have been implicated in the pathogenesis of osteoarthritis, yet their exact role, etiology, and natural history remain ... Patricia,A.,Berry,......
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Objective By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which i......
Mobasheri, A. & Batt, M. An update on the pathophysiology of osteoarthritis.Ann. Phys. Rehabil. Med.59, 333–339 (2016). ArticlePubMedGoogle Scholar Minafra, L. et al. Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility.Arthritis Res. Ther.16, R91 (2014). ...
Causes of osteoarthritis; Characteristics of osteoarthritis; Metabolic aspects of o... BP Burnett,R Levy,BJ Cole - 《Journal of Knee Surgery》 被引量: 142发表: 2006年 Analysis of limb alignment in the pathogenesis of osteoarthritis: a comparison of Saudi Arabian and Canadian cases A study was...
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joi
T. et al. Osteoarthritis: new insights. Part 2: treatment approaches. Ann. Intern. Med. 133, 726–737 (2000). Article CAS PubMed Google Scholar Blagojevic, M., Jinks, C., Jeffery, A. & Jordan, K. P. Risk factors for onset of osteoarthritis of the knee in older adults: a ...
We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the most widespread arthritis in the world, using the powerful tool of single-cell RNA-sequencing. Multiple cell types were identified based on profiling of 10,640 s