It has been postulated that renal vasoconstriction is induced either by a hepatorenal reflex related to the diseased liver or by arterial vasodilation and the subsequent baroreceptor-mediator activation of systemic vasoconstrictor factors. The diagnosis of HRS requires the exclusion of other causes of ...
At the same time enhanced formation of nitroxide leads to peripheral vasodilation; bacterial endotoxin escaping clearance by the diseased liver stimulates the expression of a long-acting nitroxide synthase. Furthermore, vasodilating intestinal mediators such as substance P escape inactivation by the liver...
Moreover, the pathogenic changes of both liver architecture and vascularisation in cirrhotic livers, as well as the lack of “true-to-life” in vitro models have impeded the development of an effective anti-fibrogenic drug. Thus, in order to identify an efficient anti-fibrogenic compound, ...
We have come a long way from the original concept of portal hypertension as a simple reflection of obstruction or fixed resistance to portal flow within the diseased liver. In an individual patient or a given clinical situation, the induction and maintenance of portal hypertension depends on the ...
Kupffer cells in the liver, microglia in the brain, and nerve-associated macrophages in the PNS. The particularity of the PNS is that peripheral nerves are spatially distributed throughout the whole body and innervate various tissue types. A description of nerve-associated macrophages in different ...
1a. a, Representative images of spleen, lung, and femurs at 4 weeks post tamoxifen injections. b, Liver and spleen weights. c, Absolute number of BM cells in BRAFV600EScl+ mice and control littermates (n = 10 mice per group). d, Hematoxylin and eosin staining and CD207 ...
147,148 Consequently, these enduring neurological complications following LT (not defined as HE since the diseased liver has been replaced with a healthy liver) not only severely weigh on the patients' health-related quality of life but also lead to longer hospitalisations. Numerous studies have ...
Localization and biological activities of melatonin in intact and diseased ga- strointestinal tract (GIT). J Physiol Pharmacol. 2007; 58(3):381-405. 17. Huether, G. The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia. ...
Careful continued tracking of ALS and frontotemporal dementia cases in the US and European cohorts who received human pituitary extracts or were exposed to diseased human CNS tissues are necessary. Retroviruses and ALS like Syndrome in Mice: One of the earliest detailed reports in the literature is...
Macrophages are considered to be the most plastic cells of the haematopoietic system [25]. Essentially, tissue macrophages are not all alike as they adopt tissue-committed roles, e.g. Kupffer cells in the liver, microglia in the brain, and nerve-associated macrophages in the PNS. The particula...