Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and failure of differentiation, leading to fulminant AML. Summary: Here...
The pathophysiology of acute illness and injury recognizes three main effectors: infection, trauma, and ischemia-reperfusion injury. Each of them can act by itself or in combination with the other two in developing a systemic inflammatory reaction syndrome (SIRS) that is a generalized reaction to ...
Objective: The crucial role of angiogenesis in the pathophysiology of acute myeloid leukemia (AML) has been proposed. Amaç: Akut miyeloid lösemi (AML) patofizyolojisinde anjiyogenezinönemli rol oynadığı ileri sürülmektedir. pmc Over the past decade, our understanding of...
Clinically, CML can be divided into three phases: the chronic phase (CP), the accelerated phase (AP), and the blast phase (BP) that resembles acute leukemia. Progression to AP and BP is associated with occurrence of additional genetic defects that cooperate withbcr/abl in leukemogenesis and ...
Polycythemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, reduced quality of life, ris... S Sirhan,L Busque,L Foltz,... - 《Clinical Lymphoma Myeloma & Leukemia》 被引量: 7发表: 2015年 Evolving Therapeutic Options for Poly...
The pathogenic role of specific tyrosine kinase mutations in various myeloproliferative neoplasms. The role of BCR-ABL in the diagnosis and targeted therapy of chronic myelogenous leukemia. The diagnostic and pathogenic role of JAK2 mutations in polycythemia vera. The diagnostic and pathogenic roles of ...
Re-evaluates the pathophysiology, clinical presentation and management of hyperleukocytic leukemias and leukostasis. Hyperleukocytosis frequency in acute m... Porcu,Pierluigi - 《Leukemia & Lymphoma》 被引量: 231发表: 2000年 Neurogenic bladder dysfunction in children: review of pathophysiology and current...
C. Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia 18, 962–966 (2004). Article CAS PubMed Google Scholar Meyer, A. N., McAndrew, C. W. & Donoghue, D. J. Nordihydroguaiaretic acid inhibits an activated fibroblast growth ...
Purpose: Donor T cells respond to minor histocompatibility antigens (mHA), resulting in both graft-versus-host disease and graft versus leukemia after allo... Y Ofran,HT Kim,V Brusic,... - 《Clinical Cancer Research An Official Journal of the American Association for Cancer Research》 被引量...
Myelodysplastic syndromes (MDS) represent a heterogeneous group of (pre)malignant bone marrow disorders characterized by an ineffective hematopoiesis and an increased propensity for the development of acute myeloid leukemia [1]. The clinical phenotypes of patients with MDS are diverse with regard to the...