ACUTE myeloid leukemiaHEMATOPOIETIC stem cellsPATHOLOGICAL physiologyBackground: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and ...
The pathophysiology of acute illness and injury recognizes three main effectors: infection, trauma, and ischemia-reperfusion injury. Each of them can act by itself or in combination with the other two in developing a systemic inflammatory reaction syndrome (SIRS) that is a generalized reaction to ...
Objective: The crucial role of angiogenesis in the pathophysiology of acute myeloid leukemia (AML) has been proposed. Amaç: Akut miyeloid lösemi (AML) patofizyolojisinde anjiyogenezinönemli rol oynadığı ileri sürülmektedir. pmc Over the past decade, our understanding of...
Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display the translocation t(9; 22) that creates thebcr/abl oncogene. The respective oncoprotein (=BCR/ABL) exhibits constitutive tyrosi...
Myelodysplastic syndromes (MDS) represent a heterogeneous group of (pre)malignant bone marrow disorders characterized by an ineffective hematopoiesis and an increased propensity for the development of acute myeloid leukemia [1]. The clinical phenotypes of patients with MDS are diverse with regard to the...
Subsequent chapters will cover the acute leukemias, aggressive tumors of early myeloid or lymphoid progenitor cells that lose the ability to differentiate, and, toward the end of the book, the diverse collection of tumors that are derived from mature lymphocytes and plasma cells. MYELOPROLIFERATIVE ...
proinflammatory cytokines that induce the recruitment of myeloid cells and the ignition of inflammatory immune responses within the plaque (Fig.1) [29]. Hence, beyond the primary events, inflammation plays a decisive role in the exacerbation of the plaque and the progression of atherosclerosis [29]...
proinflammatory cytokines that induce the recruitment of myeloid cells and the ignition of inflammatory immune responses within the plaque (Fig.1) [29]. Hence, beyond the primary events, inflammation plays a decisive role in the exacerbation of the plaque and the progression of atherosclerosis [29]...
Cervical cancer being one of the primary causes of high mortality rates among women is an area of concern, especially with ineffective treatment strategies
For aplastic anemia, the risk is increased for pancytopenia, leukemia, acute myeloid leukemia, squamous cell carcinoma, medulloblastoma, Wilms tumor, breast cancer, and liver cancer. Xeroderma pigmentosum XPA: 9q22.3 XPB/ERCC3: 2q21 XPC: 3p25 XPD/ERCC2: 19q13.2-q13.3 XPE/DDB2: 11p12-p11 ...