Ovarian cancer is associated with a high morbidity and mortality, and is the leading cause of gynecologic cancer-related death in the US. In recent years, the molecular pathophysiology of ovarian tumors has been better elucidated, allowing for the distinction of two tumor types: the more indolent...
into the molecular pathology of ovarian cancer have been gained, we remain far from a comprehensive understanding of the biology of this highly lethal ... MP Boente,J Hurteau,GC Rodriguez,... - 《Current Opinion in Oncology》 被引量: 813发表: 1993年 Origins and molecular pathology of ovarian...
The chapter is concluded with genetics and genomics of ovarian cancers. Endometrial carcinoma is the most common malignancy while ovarian carcinoma is one of the deadliest diseases of the M眉llerian tract. Thus, understanding the genetic and molecular alterations underlying these cancers is essential ...
Hereditary breast and ovarian cancer (HBOC) syndrome is most commonly characterized by deleterious germline mutations inBRCA1andBRCA2. HBOC patients are prone to the development of malignant neoplasms in multiple organs including the breast, ovary, and fallopian tube. From a pathological perspectiv...
General Classification of Ovarian Cancers All ovarian tumors, including the malignant forms ( Ovarian Cancer ), are classified into four main categories: Epithelial ovarian cancer Sex-cord stromal tumors Germ cell tumors Metastatic tumors Twenty to twenty-five percent of all ovarian tumors are ...
Moreover, endometriosis serves as a precursor of ovarian cancer (endometriosis-associated ovarian cancer; EAOC), especially of the endometrioid and clear cell subtypes. Although a variety of molecular events, such as p53 alteration, PTEN silencing, K- ras mutations, and HNF-1 activation, have ...
The BRCA1 gene is located on chromosome 17q21 and encodes a protein of 1863 aminoacid residues, which includes a zinc-finger domain.1, 2 Mutations in BRCA1 are associated with a risk of breast cancer of about 80% and a risk of ovarian cancer of 40% by age 70.3, 4 The BRCA2 gene ...
Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy p pBackground/p pOvarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In recent years... R Mehrotra,G Tyagi,DK Jangir,... - 《Journal of Ovarian...
ovarian cancer enrolled in the ICON7 trial14,15. A digital image analysis algorithm was developed to quantify CD8+T-cell densities in the tumour epithelium versus stroma compartment. Specifically, with independent curations by a pathologist, we designed an algorithm to distinguish cells of the ...
Meanwhile, morphological studies upgraded by molecular genetic studies have enabled new insights into the pathogenesis of ovarian cancer with possible consequences on future cancer screening and platinum-based treatments. It has become apparent that the different subtypes of ovarian carcinoma represent ...