The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated. Autophagy and apoptosis are two important cellular pathways that are critical for cell survival or death. The balance between apoptosis and autophagy regulates...
Cecere A, Gattoni A: The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect. Clin Ter - Marotta, Vangieri () Citation Context ...s, liver failure and HCC is common. Chronic inflammation and cirrhosis, accompanied by regenerative process, ...
Molecular pathways and targeted therapeutics in hepatocellular carcinoma. Abbreviations: APC: antigen presenting cell; AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases; CD: cluster differentiation; CTLA4: cytotoxic T-lymphocyte–assoc+iated antigen 4; ERK: extracellular...
Molecular pathogenesis of hepatocellular carcinoma by hepatitis virus infection Hepatocellular carcinoma (HCC) occurs subsequent to liver injury, where regenerative hepatocytes develop into a dysplastic nodule and then early HCC, suppo... 山下,太郎,本多,政夫,金子,周一 - 《Japanese Journal of Clinical ...
The incidence of hepatocellular carcinoma in this model corresponds to the frequency, severity, and age of onset of liver cell injury, which itself corresponds to the intrahepatic concentration of HBsAg and is influenced by genetic background and sex. Thus, the inappropriate expression of a single ...
Hepatocellular carcinoma (HCC) is one of the major causes of death among cirrhotic patients, being viral hepatitis and alcohol abuse, the main risk factors for its development. The introduction of highly sophisticated genomic technologies has spurred extensive research on the molecular pathogenesis of ...
Basic, translational & clinical studies of hepatocellular carcinoma: progress, challenges and prospectives 肝细胞癌的治疗面临着许多挑战和机遇。本专题旨在报道肝细胞癌领域的基础、转化与临床研究的最新进展、挑战和展望等。 特别关注的主题包括: 肝细胞癌的降期和转归 肝细胞癌的新辅助和系统辅助疗法 肝细胞癌肿...
Hepatocellular carcinoma (HCC) is one of the most common life-threatening malignancies in the world. This cancer generally arises within the boundaries of well-defined causal factors, of which viral hepatitis infection, aflatoxin exposure, chronic alcohol abuse, and nonalcoholic steatohepatitis are the...
Transgenic mice that overproduce the hepatitis B virus large envelope polypeptide and accumulate toxic quantities of hepatitis B surface antigen (HBsAg) within the hepatocyte develop severe, prolonged hepatocellular injury that initiates a programmed response within the liver, characterized by inflammation, ...
V. Immune pathogenesis of hepatocellular carcinoma. J. Exp. Med. 188, 341–350 (1998). CAS PubMed PubMed Central Google Scholar Nakamoto, Y. et al. Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy. J. Exp. Med. 196, ...