参考资料: [1]中国药物临床试验登记与信息公示平台官网. Retrieved Apr 15, 2024, from http://www.chinadrugtrials.org.cn/index.html [2] AstraZeneca eyes a safer PARP inhibitor, with nearly 50% response in advanced breast cancer patients: #AACR24. Retrieved April 8, 2024, from https://endpts...
NCI DoCTaD. [cited 2015 20-10-2015]; Available from: <http:// dctd.cancer.gov/ResearchResources/biomarkers/PolyAdenosylRibose.htm>. de Haan R, etc. Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials. Radiother Onco...
该篇文献是2023年4月发表在Clinical Cancer Research(IF=11.5)上,原文标题是《[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study...
[1]中国药物临床试验登记与信息公示平台官网. Retrieved Apr 15, 2024, from http://www.chinadrugtrials.org.cn/index.html [2] AstraZeneca eyes a safer PARP inhibitor, with nearly 50% response in advanced breast cancer patients: #AACR24. Retr...
2023年4月发表在Clinical Cancer Research(IF=11.5)上,原文标题是《[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a…
近日,恒瑞医药及子公司苏州盛迪亚生物医药有限公司、成都盛迪医药有限公司收到国家药品监督管理局核准签发的《药物临床试验批准通知书》,批准开展一项HRS-1167片(默克代码:M9466)联合注射用SHR-A1921或联合贝伐珠单抗或联合醋酸阿比特龙片(I)[1]及泼尼松/泼尼松龙(AA-P)治疗晚期实体瘤的Ib/II期临床研究。
Multi-drug resistance protein 1 MMR: Mismatch repair NAD: Nicotinamide adenine dinucleotide NER: Nucleotide excision repair NHEJ: Nonhomologous end-jointing PAR: Poly (ADP-ribose) PARP: Poly (ADP-ribose) polymerase PARPi: Poly (ADP-ribose) polymerase inhibitor ...
Oncology PARP Inhibitor and Platinum Drug Combination Therapies in BRCA1 and BRCA2 Isogenic Models CITY OF HOPE'S IRELL & MANELLA GRAD. SCH. OF BIOMEDICAL SCI. Timothy O'Connor ClarkCaroline CeciliaPatients with BRCA-associated breast cancers may respond differently to monotherapy with platinum ...
(35 products) has actually great psychometric properties and can be properly used in general and medical population. The Drug and Violence Resistance Educational plan (PROERD) is commonly disseminated and implemented as a public policy in Brazil. PROERD’s present curricula would be the interpretation...
Therefore, any factors that promote the recovery of HR repair function or lead to the inhibition of the NHEJ repair pathway may cause PARP inhibitor resistance. In addition, the number and functional site of PARP inhibi- tors also affect the sensitivity of drug action to a certain extent. It...