Several drugs targeting poly(ADP-ribose) polymerase (PARP) enzymes are under development. Responses have been observed in patients with germline mutations in BRCA1 and BRCA2, with further data supporting antitumour activity of PARP inhibitors in sporadic ovarian cancer. Strategies to identify other ...
Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. Oncotarget 7, 76534–76550 (2016). PubMed PubMed Central Google Scholar Berns, K. & Berns, A. Awakening of “Schlafen11” to tackle chemotherapy resistance in SCLC. Cancer Cell 31, 169–171 (2017). ...
Most notably, patients with BRCA1/2 mutant ovarian cancer benefit from maintenance treatment with PARP inhibitors after (complete or partial) response to platinum-based chemotherapy. Here, we discuss the mechanism of PARP inhibition, multiple drug resistance mechanisms, including BRCA reverse mutations,...
Predictive biomarker testing has gained significant importance in urological malignancies, especially in urothelial cancer and prostate cancer underscored by novel targeted drugs like Erdafitinib and PARP inhibitors. Furthermore, immunotherapy has emerged as a central pillar in managing kidney cancer and ...
"We have had HER2-targeted drugs — targeting the HER2 protein — but, until now, the use of tumour genomics has not really entered the practical care of breast cancer, unlike melanoma or lung cancer," said lead study author Fabrice André, a professor of medical oncology at the Institut...
the excitement about gynecologic cancers is really palpable for a number of reasons. There are some really exciting new drugs, including cellular therapeutics, immunotherapy,PARP(polyadenosinediphosphate-ribose polymerase) inhibitors, and ways of overcoming PARP resistance. Multiple new drugs as single age...
The simplest structure is blunt DSBs, and these are often referred to as “clean” breaks. These structures are preferred by c-NHEJ and will result in the rapid removal of these lesions, and therefore their toxicity is limited. Nonetheless, most chemotherapeutic drugs and radiotherapy as well ...
It is essential to distinguish between these pathways since there are different consequences to the surrounding cells in terms of inflammatory responses. Additionally, Kasof says that there are therapeutic drugs that target these pathways. As an example, he says that in cancer cells, apoptotic resist...
Whether there are master regulatory genes impact many different types of NPs, or the reverse, if the NPs as LNC loaded with drugs based on proteins would affect target genes in a different manner between infected and normal cells, or an effect different from the free mRNA effect on this ...
For example, PARP inhibitors block the proteins inside cells that prevent them from repairing damaged DNA, which makes it difficult for tumor cells to grow. Some people have mutations in the genes of these DNA repair proteins that stop them from working as they should. The drugs are helpful ...