(1)DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. (2)PARP inhibitors: Synthetic lethality in the clinic. (3)Targeting DNA damage response in cancer –past, present and future. (4)Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies. (5) https...
(1)DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. (2)PARP inhibitors: Synthetic lethality in the clinic. (3)Targeting DNA damage response in cancer –past, present and future. (4)Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies....
[1] PARP inhibitors: Synthetic lethality in the clinic [2] Stocking oncology's medicine cabinet
[1] PARP inhibitors: Synthetic lethality in the clinic [2] Stocking oncology’s medicine cabinet
3. 优化组合疗法。这一目标可以通过以下手段达成:进一步了解组合疗法成功的机理,确定能够靶向药物抗性的组合疗法和发现可以预测PARP抑制剂组合疗法疗效的生物标记物。 参考资料: [1] PARP inhibitors: Synthetic lethality in the clinic [2] Stocking oncology's medicine cabinet...
虽然临床使用PARPi的契机越来越多,但是你真的完全了解PARPi的作用机制了吗?本期文献精读我们诚邀南昌大学第二附属医院肿瘤科兰琼玉教授,她将为大家分享一篇发表在《Science》杂志上的综述:《PARP inhibitors: Synthetic lethality in the clinic》。 00:000:00音频...
[5].Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science. 2017;355(6330):1152-1158. doi:10.1126/science.aam7344 [6].Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 1980;283(5747):593-596. doi:10.1038...
[5].Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science. 2017;355(6330):1152-1158. doi:10.1126/science.aam7344 [6].Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 1980;283(5747):593-596. doi:10.1038...
[9].Farmer H, Mccabe N, Lord C J, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.[J]. Nature, 2005, 434(7035): 917-921.DOI:10.1038/nature03445 [10].Lord C J, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic[J]. Science, 2017...
[5].Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science. 2017;355(6330):1152-1158. doi:10.1126/science.aam7344 [6].Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 1980;283(5747):593-596. doi:10.1038...