PNH是一种慢性破坏性、威胁生命的疾病,研究显示,若得不到有效治疗,PNH患者5年死亡率约为35%。PNH虽然以溶血为主要症状,导致反复的血红蛋白尿和持久的贫血,但其危害不仅限于此。更严重的是由溶血引起的并发症包括血栓,肾功能障碍,肺动脉高压等,是引起PNH患者死亡的重要原因。其中血栓是最危险的并发症之一。 2. ...
Official website for PNH patients and their caregivers. Paroxysmal nocturnal hemoglobinuria (PNH) is an ongoing, progressive disease. Increase your knowledge about the disease here.
阵发性睡眠性血红蛋白尿(paroxysmal nocturnal hemoglobinuria,PNH)系后天获得性的红细胞膜缺陷引起的对补体激活异常敏感的慢性血管内溶血,常睡眠时加重,可伴间歇性血红蛋白尿和全血细胞减少症或反复血栓形成。 病因和发病机制 PNH 是由于红细胞膜上缺乏抑制补体激活及膜反应性溶解的蛋白质所致。该类膜蛋白夹有十余种,...
PNHタイプ血球Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and complex disease caused by clonal expansion of hematopoietic stem cells that have acquired a somatic, loss-of-function mutation in the phosphatidylinositol glycan anchor biosynthesis, class A gene. The blood cells generated by such ...
例句 释义: 全部 更多例句筛选 1. Objective: To study the effect of T-lymphocytes on hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria(PNH). 目的:研究阵发性睡眠性血红蛋白尿症(PNH)患者的T淋巴细胞对造血祖细胞的影响。 dictsearch.appspot.com©...
Get the latest information on paroxysmal nocturnal hemoglobinuria (PNH) including news, research, treatments, clinical trials, patient stories, and more.
Paroxysmal nocturnal haemoglobinuria is an ultra-rare disease and potentially life-threatening disease. Learn more about the causes, symptoms, and unmet needs.
Patients should be tested at least once for paroxysmal nocturnal hemoglobinuria (PNH) if they have any of the following [26] : Evidence of hemoglobinuria Unexplained hemolysis (increased lactate dehydrogenase [LDH] level, absent haptoglobin) Abdominal or cerebral vein thrombosis Thrombocytopenia, mac...
Because paroxysmal nocturnal hemoglobinuria is rare with unclear symptoms, you may have it a while before treatment. Learn more about this blood disorder.
paroxysmal nocturnal hemoglobinuria An acquired hemolytic disease, due to proliferation of an abnormal clone(s) of myeloid stem cells, the progeny of which are susceptible to complement-mediated membrane damage and hemolysis–CMH Clinical Thromboses, ↑ infections; PNH may evolve into aplastic or sidero...