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Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensional (3D) differentiation of expandable midbrain floor plate neural ...
Parkinson's disease (PD) is a debilitating neurodegenerative disorder, for which people above the age of 60 show an increased risk. Although there has been great advancement in understanding the...doi:10.1007/s12041-018-0960-6Ghatak Swagata...
A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model. Angew Chem ... G Mugesh,N Singh,MA Savanur,... - 《Angewandte Chemie》 被引量: 17发表: 2017年 Resveratrol Suppresses TNF-Induced Activation of Nucle...
A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology that impact the disease course for each patient: the anatomical location of the initial α-synuclein inclusion, and α...
Although there is no cure, medicines, surgical treatment and other therapies can treat the symptoms of PD. Levodopa/carbidopa remains the most common and effective medication and is on the WHO Model List of Essential Medicines. Other me...
targets for treatment. The model predicts that combined tools, initiated as early as possible and targeting a wide range of pathways, are the most effective ones. As one can observe, most works that address PD automatic recognition cope with voice-based data. Procedures to identify voiced and ...
Although there is no cure, medicines, surgical treatment and other therapies can treat the symptoms of PD. Levodopa/carbidopa remains the most common and effective medication and is on the WHO Model List of Essential Medicines. Other medications, such as anticholinergics, or therapies such as deep...
Parkinson’s disease; imaging biomarkers; machine learning; stacked model; classification; dopamine level; disease progression1. Introduction Parkinson’s disease (PSD) is a progressive neurodegenerative disease of the brain which causes the loss of dopamine neurons at every stage of the disease. It ...
The imbalanced dataset will not help the machine learning model perform successfully. Many academics have overlooked this problem, but it has an impact on the classification system’s performance. Oversampling and undersampling approaches can be used to tackle this problem. In some research, the ...