Further characterisation of the LPS model of Parkinson's disease: a comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat. Brain, behavior, and immunity. 2013; 27(1):91-100....
In LPSmodel,expression of iNOS in microglial cells increased firstly and then recovered. It suggested dynamic change of LPS-in-duced inflammatory respouse.【Key words】 Parkinson’disease;iNOS;microglial cells;neuroinflammation;cellular culture帕金森病(Parkinson’s disease,PD)的病理变化为黑质致密部...
细胞的存在，证实帕金森病（Parkinson＇s Disease ，PD ）发病机制与外周炎症有关［1］。帕金森病的病因在很大程度上归因于 黑质内多巴胺（DA ）神经元逐渐退化，其中小胶质细胞活化介导的炎症反应作用最为关键，因此小胶质细胞活化及其产生的炎症因子是导致DA 神经元退化及死亡的重要原因。建立体外小胶质细胞培养体系及...
To evaluate the effect of lipoic acid(LA) on LPS-induced Parkinson disease(PD) model of mice. Female C57BL/6 mice of 10-month-old were randomly divided into saline control group, PD group and LA group. The PD mouse model was induced by intranasal instillation of LPS. Assays of tyrosine...
Parkinson's disease (PD) is an idiopathic and progressive neurodegenerative disease characterized by the loss of ~80% of dopaminergic neurons in substantia nigra pars compacta (SNpc). Because activation of the innate cellular immune response, mediated by microglia, has been linked to the ...
Differential Effects of LPS and 6-OHDA on Microglia's Morphology in Rats: Implications for Inflammatory Model of Parkinson's Disease Parkinson's disease (PD) is an idiopathic and progressive neurodegenerative disease characterized by the loss of ~80% of dopaminergic neurons in substantia... I Parra...
关键词: 神经退行性疾病 小胶质细胞 NO 优克那非 N-乙酰半胱氨酸 数学建模 I ABSTRACT Neurodegenerative diseases that affect human health, the general term for a class of diseases, including Alzheimer's disease, Parkinson's disease. Microglia in central nervous system play an important role in t...
Parkinson's disease (PD), a frequent degenerative disease in the elderly, is characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc). Neuroinflammation caused by over-activated microglia plays a crucial role in the pathogenesis of PD. Tubeimoside I (TBMS1) has...
Multiple risk factors contribute to the progression of Parkinson’s disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechani
butdidnotaffectcellviability.ConclusionLPS(1mg·L)stimulationofprimarycuhuredmicrogliaandLPS(10mg·L)stimulationoftheBV2microgliacancreateastablemodelofmicrogliaactivation.Keywords:LPS;microglia;activation;model研究表明帕金森患者脑部有T淋巴细胞和活化的小胶质细胞的存在,证实帕金森病(Parkinson~Disease,PD)发病机制...