Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation, which is marked by microglial activation, plays a very important role in the pathogenesis of PD. Pro-inflammatory mediators produced by activated microglia could ...
目的评价氢对LPS致BV-2小胶质细胞炎症反应的影响及自噬在其中的作用。 方法体外培养BV-2小胶质细胞,接种于6孔板或96孔板,采用随机数字表法分为4组( n=24):对照组(C组)、脂多糖组(LPS组)、富氢液培养基组(H组)和自噬抑制剂3-甲基腺嘌呤组(3-MA组)。C组应用10%胎牛血清MEM培养基培养24 h;LPS组加入LP...
Parkinson's disease (PD) is an idiopathic and progressive neurodegenerative disease characterized by the loss of ~80% of dopaminergic neurons in substantia nigra pars compacta (SNpc). Because activation of the innate cellular immune response, mediated by microglia, has been linked to the ...
细胞的存在，证实帕金森病（Parkinson＇s Disease ，PD ）发病机制与外周炎症有关［1］。帕金森病的病因在很大程度上归因于 黑质内多巴胺（DA ）神经元逐渐退化，其中小胶质细胞活化介导的炎症反应作用最为关键，因此小胶质细胞活化及其产生的炎症因子是导致DA 神经元退化及死亡的重要原因。建立体外小胶质细胞培养体系及...
Neurodegenerative diseases that affect human health, the general term for a class of diseases, including Alzheimer's disease, Parkinson's disease. Microglia in central nervous system play an important role in the inflammatory process. Moderate microglia activation has a protective effect on neurons, bu...
Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the alpha2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease Brain Behav. Immun., 69 (2018), pp. 456-469 ...
In LPSmodel,expression of iNOS in microglial cells increased firstly and then recovered. It suggested dynamic change of LPS-in-duced inflammatory respouse.【Key words】 Parkinson’disease;iNOS;microglial cells;neuroinflammation;cellular culture帕金森病(Parkinson’s disease,PD)的病理变化为黑质致密部...
diseases,includingAlzheimefsdisease,Parkinson f sdisease.Microgliaincentralnervous systemplayanimportantroleintheinflammatoryprocess.Moderatemicrogliaactivationhas aprotectiveeffectonneurons,butexcessiveactivationofmicrogliareleaselargeamountsof neurotoxicfactors,suchasnitricoxide(NO),theneuraltoxicityfactorwillleadto ...
教授,硕士生导师, 研究方向: 神经免疫药理学,E-mail: yinyanyan5678@ 126. com陈寒青,男,副教授,硕士生导师,研究方向: 功能性食品与开发,E-mail: hangchen@ yahoo. com. cn研究表明帕金森患者脑部有 T 淋巴细胞和活化的小胶质细胞的存在,证实帕金森病( Parkinson's Disease,PD) 发病机制与外周炎症有关[1]...
modelofmicrogliaactivation. Keywords:LPS;microglia;activation;model 研究表明帕金森患者脑部有T淋巴细胞和活化的小胶质 细胞的存在,证实帕金森病(Parkinson~Disease,PD)发病机制 与外周炎症有关⋯。帕金森病的病因在很大程度上归因于 黑质内多巴胺(DA)神经元逐渐退化,其中小胶质细胞活化介 ...