Parkinson's disease (PD) is late-onset, progressive neurodegenerative, and hypokinetic movement disorder characterized by relatively selective degeneration of nigrostriatal dopaminergic neurons and presence of fibrillar cytoplasmic inclusions containing 伪-synuclein and ubiquitin. Major pathological features of ...
disease process, much of this process still remains unknown. A range of animal models has been used to study the pathogenic mechanisms and evaluate potential therapies of Parkinson’s disease. Two main types of models based on administration of toxins, either locally (6-hydroxydopamine, 6-OHDA; ...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model remains the most commonly used animal model of Parkinson's disease (PD). There are three MPTP-treatment schemes: acute, subacute and chronic. Considering the advantages of the period and similarity to PD, the subacute model was...
GRK6 levels were found to be altered in Parkinson's Disease (PD) and D2 dopamine receptors are supersensitive in mice lacking GRK6 (GRK6-KO mice). To understand how GRK6 modulates the behavioral manifestations of dopamine deficiency and responses to L-DOPA, we used three approaches to model...
Methodological Strategies to Evaluate Functional Effectors Related to Parkinson's Disease Through Application of Caenorhabditis elegans Models Locke CJ, Fox SA, Caldwell GA et al (2008) Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson’s disease. Neurosci Lett ... KA ...
Inter and intracellular mitochondrial transfer: future of mitochondrial transplant therapy in Parkinson's disease Biomed Pharmacother, 159 (2023), Article 114268 2023/03/01/ View PDFView articleView in ScopusGoogle Scholar [7] A. Bose, M.F. Beal Mitochondrial dysfunction in Parkinson's disease J ...
Functional neuro-imaging studies of Parkinson's disease (PD) patients and animal models show inconsistent cortical responses to sensory stimulation: some p... G Pelled,H Bergman,T Ben-Hur,... - 《European Journal of Neuroscience》 被引量: 55发表: 2005年 Basal ganglia oscillations and pathophys...
Parkinson’s disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the consequent striatal DA deficiency. Ye...
Many animal experimental studies have been performed to investigate the efficacy of acupuncture in Parkinson's disease (PD). Sex differences are a major issue in all diseases including PD. However, to our knowledge, there have been no reviews investigating sex differences on the effectiveness of ac...
carried out in Canada show that docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, might reduce levodopa-induced dyskinesias (LIDs) in nonhuman primate models of Parkinson's disease and could potentially be used as a safe and effective treatment for patients with this disease.doi...