Parkinson’s diseasePreformed fibrilsPropagationStereotaxic injectionα-synucleinParkinson's disease (PD) is pathologically characterized by intraneuronal α-synuclein (α-Syn) inclusions called Lewy bodies (LBs) and the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Autopsy ...
Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of pro
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we analyze human neural precursor cells (hNPCs) from sporadic PD (...
An appropriate model should be chosen after considering both the context of the research and the model properties. This review addresses the validity, strengths, and limitations of current PD mouse models for translational research. 展开 关键词: Animals Humans Mice Parkinson Disease Disease Models, ...
Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease Parkinson's disease (PD) is recognized as the second most common neurodegenerative disorder after Alzheimer's disease. PD is mainly characterized by a sele... S Pain,A Gochard,S Bodard,... - 《Experimental & ...
in adulthood, and blocking Ca1.3 Cachannels in adult neurons induces a reversion to the juvenile form of pacemaking. Such blocking ('rejuvenation') protects these neurons in bothandmodels of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease...
圆圆援愿员;砸猿源缘援源;砸苑源圆援缘;砸苑源缘援苑; 砸怨苑苑援猿 摘要:目的摇探讨胆绿素还原酶月(遭蚤造蚤增藻则凿蚤灶鄄Ⅸβ则藻凿怎糟贼葬泽藻, 月灾砸月)在员鄄甲基鄄源鄄苯基鄄员,圆,猿,远鄄四氢吡啶(员鄄皂藻贼澡赠造鄄源鄄责澡藻鄄 灶赠造鄄员,圆,猿,远鄄贼藻贼则葬澡赠凿则...
In addition to the cardinal motor symptoms associated with Parkinson’s disease (PD), there are also several nonmotor symptoms that can occur, many of which can significantly affect the quality of life of patients. These nonmotor symptoms are currently of interest because they may provide new ...
The pathological hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) with aggregated α-synuclein being the major component. The abnormal α-synuclein aggregates transfer between cells, recruit endogenous α-synuclein into toxic LB
Glucose metabolism is dysregulated in Parkinson’s disease (PD) causing a shift toward the metabolism of lipids. Carnitine palmitoyl-transferase 1A (CPT1A) regulates the key step in the metabolism of long-chain fatty acids. The aim of this study is to ev