Chan C Savio,Guzman Jaime N,Ilijic Ema,Mercer Jeff N,Rick Caroline,Tkatch Tatiana,Meredith Gloria E,Surmeier D James.’Rejuvenation’ protects neurons in mouse models of Parkinson’s disease.Nature. 2007Chan CS , Guzman JN , Ilijic E , Mercer JN , Rick C , Tkatch T et al . ( ...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized in advanced stages by motor disabilities which are mainly due to the loss of dopaminergic neurons (DAn) in the substantia nigra pars compacta1. However, PD is known as a gradual-onset condition with a long-defined preclinical...
Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neurons on L-type Ca1.3 Cachannels to drive their maintained, rhythmic pacemaking renders them vulnerable to...
Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet the mechanisms and exact contribution of these cells to the neurodegeneration remains poorly understood. In this study, we induced progressive dopamin
Parkinson´s disease (PD) is an age-related neurodegenerative disorder characterized by a loss of nigral dopamine (DA) neurons that project their axons to the striatum. Striatal DA depletion causes the typical motor symptoms of PD. Another key feature of PD are intracellular protein inclusions ...
However, it is clear that L-DOPA and the receptor agonists provide only limited ameliorable treatment and that most patients inexorably become progressively debilitated regardless of the type of therapy. On the other hand, an alternative approach in the therapeutic management of Parkinson's disease ...
Parkinson’s disease;selenium;sodium selenite;seleno-L-methionine;selenoproteins 1. Introduction Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects about 10 million people worldwide [1]. The pathogenic mechanisms of PD are not fully clarified, but its main ...
Using new one-of-a-kind "mouse models" that promise to have a significant impact on future Parkinson's disease research, Mount Sinai School of Medicine researchers are among the first to discover how mutations in a gene called LRRK2 may cause inherited (or "familial") Parkinson's disease,...
Loss of afferent-mediated trophic support contributes to neuronal loss in common neurodegenerative diseases, in- cluding Alzheimer's disease [17, 18] and Parkinson's disease [19–21]. Trophic support from the major glutamatergic striatal afferent systems may also play an important role in © The...
Food Funct Comparative study on the effects of phosphatidylserine rich in DHA and EPA on A¦Â-intervened Alzheimer's disease using cell models 33876786 Int J Neurosci Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: th...