Department of Paediatric Anaesthesia and Acute Pain ManagementArchives of disease in childhoodR. M. Beringe, J. P. Thompson, S. Parry, P. A. Stoddart, "Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines," Arch Dis Child., vol. 96, pp. 307-8,...
Various studies have also reported acute liver failure (ALF) due to single-dose overdose or repeated exposure to supratherapeutic doses of paracetamol [6]. Data on paracetamol overdose from Sub-Saharan Africa is limited [7]. Poor understanding of paediatric dosing has resulted in reported overdose...
Given in the right dosage it is not associated with many side effects; however prolonged use may produce renal injury and massive overdose may produce hepatic injury [1]. It is the most common pharmaceutical agent involved in overdose particularly below the age of 6 years [2, 3]. There ...
Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxic... Paracetamol is involved in a large proportion of accidental paediatric exposures and deliberate self-poisoning cases, although subsequent hepatic fail...
[51]. Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults followingsingle acute overdose[52,53,54,55]. However, further retrospective case series have identified liver injury ...
Conclusions: Paracetamol was commonly given to children on “self prescription” basis and the tablet formulation was most frequently used, with the possibility of misuse and overdose. Caregivers need to be educated on age- appropriate formulations which are less likely to lead to overdose. Keywords...
BackgroundIn children, paracetamol overdose due to deliberate self-poisoning, accidental exposure or medication errors can lead to paediatric acute liver f... J Rajanayagam,JR Bishop,PJ Lewindon,... - 《Archives of Disease in Childhood》 被引量: 33发表: 2014年 Introduction to suicide and self...
P15 Using prescribing nudges to reduce medication errors: paracetamol on paediatric intensive care Aim Paracetamol is widely available and its safety profile is relatively good. However, the risk associated with a paracetamol overdose is much greater in a neonate than that associated with an adult. ...
Paracetamol poisoning in adults is practically invariably due to deliberate ingestion of an overdose. Approximately one fifth of the poisoned individuals present medical problems, particularly in the form of liver damage. About five per cent develop hepatic coma associated with a high mortality. Serious...
Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxic... Paracetamol is involved in a large proportion of accidental paediatric exposures and deliberate self-poisoning cases, although subsequent hepatic fail...