In order to improve outcomes in patients presenting with paracetamol overdose, the UK's Commission on Human Medicines (CHM) updated its recommendations for the use of acetylcysteine in September 2012. The revised guidelines suggested: using a lower treatment threshold (`100mg/L' nomogram line for ...
Short report:Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines Two cases of 10-fold accidental overdose with intravenous paracetamol are presented. Case 1: A 5-month-old child with intussusception received 90 mg/kg int... RM Beringer,JP Thompson,S Pa...
This guideline will cover single overdoses, or staggered ingestions over a period of less than 8 hours of the immediate-release preparation of paracetamol. Supra-therapeutic overdoses of >60mg/kg/day in children (>4g/day in adults), or those involving modified release preparations (e.g. Pana...
The paracetamol nomogram is used to assess the need for treatment in acute immediate release paracetamol ingestions with a known time of ingestion. Cases that require different management include modified release paracetamol overdoses, large or massive overdoses, accidental liquid ingestion in children, ...
Background: Management of serious paracetamol overdose with N-acetylcysteine (NAC) is an effective strategy. Early treatment with NAC prevents the formation of a toxic metabolite that leads to hepatic injury. However, inappropriate treatment with NAC and overtreatment with NAC can lead to potential ad...
HepatotoxicityParacetamolOtherWe present a case of intravenous (IV) paracetamol overdose in a nutritionally malnourished child during hospital admission. A ten-... Ingrid,Berling,Michael,... - 《Clinical Toxicology》 被引量: 18发表: 2011年 Fatal acute liver damage caused by a therapeutic dose of ...
The current guideline for Panadol Osteo® poisoning would have detected all cases requiring NAC treatment. Links Publisher Full Text (DOI) Authors+Show Affiliations Graudins A MeSH AcetaminophenAcetylcysteineAdolescentAdultAgedAged, 80 and overChildC...
The outcomes of this trial may impact the clinical guideline recommendations concerning first analgesic treatment options in acute low back pain in general practice. Recruitment of eligible patients is currently ongoing. Substantial protocol amendments will be communicated to participants, cooperating GPs ...
The authors have developed and present here an evidence based flowchart that will guide clinicians step by step through the investigation and treatment of all patients presenting to hospital after this common, but often difficult to manage overdose. As well as a management guideline this flowchart ...
is readily used, following United Kingdom guideline, it is safe to use an ingested dose of >150mg/kg as the cut-off value for N-acetylcysteine treatment with risk stratification for hepatotoxicity if the patient is ≥14years and visit the ED within 15h after an acute paracetamol overdose....