Case presentation: We present a case of acute kidney injury without hepatotoxicity in paracetamol overdose. A 15-year-old girl was admitted 48 h after she had taken 10 g of paracetamol. She was complaining of abdominal pain and vomiting. Her blood level of creatinine was 1.20 mg/dL on ...
Paracetamol poisoning and the kidney. J Clin Pharm Therap 1993;18:5–8. Mahmoudi GA, et al. N-aceylcysteine overdose after acetaminophen poisoning. Int Med Case Rep 2015;8:65–69. Ershad M, Naji A, Vearrier D. N acetylcysteine. In: StatPearls. Treasure Island (FL): StatPearls ...
Case presentation: We present a case of acute kidney injury without hepatotoxicity in paracetamol overdose. A 15-year-old girl was admitted 48 h after she had taken 10 g of paracetamol. She was complaining of abdominal pain and vomiting. Her blood level of creatinine was 1.20 mg/dL on ...
The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug...
Everyday, long-term use (several months or more) of paracetamol can cause liver or kidney damage. People taking this medication in the usual way for shorter periods of time have not had these problems. These are not all of the possible side effects of this medication. ...
Six patients with liver damage following paracetamol overdose, one patient with viral hepatitis and six control subjects were infused with sodium L(+) lact... O C.,Record,and,... - 《Metabolism-clinical & Experimental》 被引量: 160发表: 1981年 Paracetamol induced hepatotoxicity Accidental or in...
doses of paracetamol (overdoses) cause acute hepatic necrosis as a result of depletion of glutathione and of binding of the excess reactive metabolite to vital cell constituents. This damage can be prevented by the early administration of sulfhydryl compounds such as methionine and N-acetylcysteine....
weight should be used to calculate the toxic paracetamol dose and actual pregnant body-weight to calculate the antidote dose. dosage errors with intravenous paracetamol have been reported, particularly in young children; rarely, such errors have resulted in substantial overdoses and liver damage.36·...
2. Liver and kidney damage: Long-term large-scale administration can cause liver and kidney damage and thrombocytopenia, and even jaundice, oliguria, acute severe hepatitis, leading to coma and death. High-dose administration may also cause nausea, vomiting, stomach pain, stomach cramps, diarrhea,...
Paracetamol overdose is common. If left untreated, liver and/or renal failure can develop. Administration of the antidote, acetylcysteine, within 8–10 hours of overdose minimizes or prevents liver damage. After overdose, the tests used to identify that patients are at risk of liver injury are ...