Table S2. Summary of PAR-CLIP Datasets, Related to Figures 2–5 Table S3. List of Sequences Used for Binding Motif Finding, Related to Figures 2–4 Table S4. CCRs Derived from AGO- and TNRC6-PAR-CLIP, Related to Figure 5 Table S5. miRNA Profile of FLAG/HA-AGO1-4-HEK293 Cells, ...
(PAR-CLIP) analysis reveals that AUF1 primarily recognizes U-/GU-rich sequences in mRNAs and noncoding RNAs and influences target transcript fate in three main directions. First, AUF1 lowers the steady-state levels of numerous target RNAs, including long noncoding RNANEAT1, in turn affecting ...
PAR-CLIP(photoactivatable-Tibonucleoside-enhanced crosslinking and immunoprecipitation,光活化增强的交联免疫沉淀)是一种新的高通量检测与特定蛋白相互作用的RNA的位点实验技术。PAR-CLIP利用一类具有光活性的核糖核苷类似物(如4-硫尿核苷,4-SU)在细胞培养过程中掺入到新转录的RNA中,活细胞在紫外光(365nm)照射时,RNA...
PaperClip Download: Download audio (4MB) Graphical Abstract Download: Download high-res image (386KB) Download: Download full-size image Highlights ► A C-terminal domain in septin-associated kinases binds negatively charged lipids ► Crystal structures reveal that this is a kinase associated-1...
口服施用GSK3787(10mg/kg)导致C57BL/6雄性小鼠的血清Cmax为2.2±0.4μM。口服施用GW0742导致野生型小鼠结肠上皮中Angptl4和Adrp mRNA(已知PPARβ/δ靶基因)的表达增加,并且在Pparβ/δ-无效小鼠结肠上皮中未发现这种效应。 GSK3787与GW0742的共同施用有效地阻止配体诱导的野生型小鼠结肠上皮中Angptl4和Adrp mRNA...