通过FISH和PLA实验,研究人员进一步证实了这些alt-NHEJ组分都定位于ecDNA上,并且抑制上游的alt-NHEJ因子(如PARP抑制剂Olaparib或PLK1抑制剂Volasertib)会降低下游因子(如LIG3和POLQ)在ecDNA上的定位。 此外,研究发现在细胞分裂期(mitosis),ecDNA...
【Cancer cell】乳腺癌的第三代分子分型:有望提升临床应答率 最新一期的cancer cell杂志,以“Response-based molecular subtyping—emergence of the third generation of breast cancer subtypes”为题,报道了乳腺癌的第三代分子分型,对乳腺癌...
Cell Meter™ Cell Viability Assay Kit *Blue Fluorescence* 价格: ￥2604/支 产品详情:简要概述 Cell Meter 细胞活性检测试剂盒是美国AAT Bioquest生产的用于细胞活性检测的试剂盒 ,Cell Meter检测试剂盒是一类... 纯度:98% 包装规格:1 kit 用途:Research Grade 货号:CS22785 品牌:AAT Bioquest 产地:American...
检测波长: Cell Counting Kit-8 (450 nm), Cytotoxicity LDH Assay Kit-WST® (490 nm) 使用Mitomycin C 检测检测HeLa细胞毒性。通过使用Cell Counting Kit-8和Cytotoxicity LDH Assay Kit-WST® [货号: CK12]两种方法检测。Cell Counting Kit-8以细胞活性为指标,Cytotoxicity LDH Assay Kit-WST以游离的LDH...
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based processes such as replication, which is counteracted through proteolysis-mediated DPC removal by spartan (SPRTN) or the proteasome. However...
Details of the assay have been described previously31. Briefly, cells were cultured in DMEM supplemented with 10% FBS and plated in plastic 96-well plates. Cells were treated with formaldehyde or irradiated with UV light (254 nm UVC), followed by incubation for RRS. The RRS levels were me...
Tankyrase 1 (PARP )检测试剂盒价格:价格电议产品详情:端粒是真核细胞染色体末端的一个特殊结构,由一段具有特定重复序列的DNA和端粒结合蛋白组成,是维持染色体结构稳定的重要因素。... 试剂盒相关产品报价更多> 产品标题价格产地公司名称更新日期 tp 试剂盒 tp 试剂盒电议U.S.A、E...上海研域商贸有限公司2023-04...
(ACD). Alternatively, cell death can occur via dedicated molecular pathways that may be controlled either through pharmacologic or genetic means, and this is referred to as regulated cell death (RCD). Classically, cell death is categorized into three different types, based on morphological changes,...
Consequently, we investigated whether DX2 also binds to PARP-1. In a pull-down assay with PARP-1, the binding affinity of DX2 to PARP-1 was found to be stronger than that of AIMP2 (Fig. 1f), suggesting that DX2 has the potential to modulate neuronal cell fate in contrast to AIMP2 ...
一、检测Caspase活性 ①caspase对角蛋白18的裂解作用 产品名及货号:M30 CytoDEATH 12140349001 M30 CytoDEATH,Fluorescein 12156857001 ②Caspase-3活性 产品名及货号:Caspase 3 Activity Assay 12012952001 ③Caspase 产品名及货号:Homogeneous Caspase Assay,fluorimetric 03005372001 ④Caspase对RARP的裂解作用 产品名及货号:...