www.nature.com/scientificreports OPEN received: 03 October 2016 accepted: 04 January 2017 Published: 31 January 2017 Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells Lu Liu1, Na Zhang1,Yueying Dou1, Genxiang Mao2, Chongwen...
tumor desmoplasia and stiffness, reduces cancer cell invasion and metastasis, improves tumor perfusion and enhances the efficacy of chemotherapy in the autochthonous genetically engineered KPC model, while also demonstrating antifibrotic effects in human patient-derived xenograft models of pancreatic cancer. ...
Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated
pancreatic cancer is often asymptomatic until later stages, and diagnosis can be difficult. However, through healthy lifestyle choices and natural support strategies, you can protect your body and improve your health
(nab) paclitaxel confers a median survival benefit of roughly 4-month over single-agent gemcitabine3,4. The overall median survival of patients with metastatic pancreatic cancer in the modern era is just 8–11 months, and the five-year survival rate is around 3%5. The relative ineffectiveness ...
Acridine orange conjugated pol- ymersomes for simultaneous nuclear delivery of gemcitabine and doxorubicin to pancreatic cancer cells. Bioconjug Chem. 2016;27: 762-771. doi:10.1021/acs.bioconjchem.5b00694.Anajafi, T.; Scott, M. D.; You, S.; Yang, X.; Choi, Y.; Qian, S. Y.; Mallik...
Altogether, these data demonstrate the need to repurpose inhibitors of NHE1, such as cariporide, for use in the oncological context and especially in treatment of PDAC [18]. Materials and Methods Cell Culture Experiments were performed on well-established human pancreatic cancer cell lines: PANC-...
Introduction: Around 3.5 million new cancer cases and 1.7 million deaths per year in Europe make cancer a critical public health problem, regarding both early diagnosis and treatment. The design and development of novel nanosystems integrating advanced functionalized nano-sized core particles and active...
Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake, and redox needs through metabolic reprogramming
Pancreatic cancer (PC) is one of the leading causes of mortality rate globally and is usually associated with obstructive jaundice (OJ). Up to date, there is no clear consensus on whether biliary decompression should be performed prior to surgery and how high levels of serum bile affects the ...