Borderline resectable pancreatic cancer:This means that cancer has spread to other organs, tissues, or blood vessels. Your surgeon may still be able to remove it, but there is a higher chance that they can only remove some of the cancer cells but not all. Locally advanced pancreatic cancer:S...
P Berthezene1, L Bartholin2, P Chan3, E Calvo4, JL Iovanna1, S Vasseur1, F Guillaumond1 and R Tomasini*,1 Advances made in pancreatic cancer therapy have been far from sufficient and have allowed only a slight improvement in global survival of patients with pancreatic ductal adenocarcinom...
et al. Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer Therapy. Cancer Research 69, 1924–1932, doi: 10.1158/0008-5472.can-08-2627 (2009). 34. Bae, D. & Ceryak, S. Raf-independent, PP2A-dependent MEK ...
Alternatively, mitochondria can be treated as individual agents that undergo fission/fusion dynamics, and the overall mitochondrial network mass, structure, and quality can be evaluated59,60,61. Patel and coworkers35devised an agent-based model (ABM) to simulate mitochondrial movement, fission, fusion...
Mifepristone inhibits LIFR signalling and reverses STAT3 phosphorylation induced by LIF. Together, these data support the repositioning of mifepristone as a potential therapeutic agent in the treatment of PDAC. Keywords: LIF/LIFR axis; pancreatic cancer; mifepristone; cyclins; cell cycle; gemcitabine; ...
Pancreatic cancer is one of the most common causes of death in Taiwan. Previous studies have shown that more than 90% of pancreatic cancer cells presented epidermal growth factor receptor (EGFR) cell marker, and this marker is thought to be important as it is related to activation of cancer ...
Pancreatic cancer accounts for only 3% of cancer cases but is the 3rd leading cause of cancer mortality in the United States [1]. Notable improvements have been made over the past decade, particularly in regard to systemic therapy and radiation delivery technique. Generally, the treatment approach...
Pancreatic ductal adenocarcinoma (PDAC) continues to have a particularly poor prognosis due to limited effective treatment options [1]. Moreover, PDAC is typified by high degrees of metabolic diversity and plasticity [2], which allows cancer cells to adjust their metabolism to fluctuations in local...