TCGA Pan-Cancer analysis project: Pan-Cancer analysis project 是 TCGA 项目的一部分,于 2012 年启动,旨在利用 TCGA 数据库中不同类型的肿瘤中产生的大量数据(DNA、RNA、表观、蛋白水平),进行整合分析,寻找潜在非肿瘤特异的的肿瘤标志与靶点,并通过增加样本量以期识别出更多肿瘤特异的分子异常。 好词好句 单词 ...
你好， pan-cancer analysis 的中文翻译是：潘癌分析 求采纳，谢谢亲！
Methods and resultsIn this study, we used The Cancer Genome Atlas (TCGA) analysis databases to explore the expression level and prognostic significance of ESM1 in 33 types of human cancer. ESM1 was shown to be over-expressed in 12 cancer types, including BLCA, BRCA, COAD, CHOL, ESCA, ...
1. Landscapes of myeloid cells in 15 cancer types revealed by scRNA-seq analysis Fig 1A:为了得到TIMs的deep transcriptional atlas,作者对15个癌肿的210个病人的380个组织 (自己测了一部分,也整合了此前发表的样品) 进行了分析,得到了138161个髓系细胞。 Fig 1B:每个癌肿的病人数 Supplemental Fig 1A:每...
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their
今天阅读了一篇较早的TCGA项目组在2013年发表于Nature的评论文章,题目为The Cancer Genome Atlas Pan-Cancer analysis project。虽然文章有一点老,但出于对TCGA的了解与理解,还是很有学习意义。 TCGA已经描绘并分析了大量的人类癌症多组学数据,因此可以整合相应数据,挖掘跨癌症类型的分子特征,并为临床治疗提供帮助。
今天要和大家分享的是今年5月份发表在Frontiers in oncology(IF:6.244)上的一篇单基因泛癌文章:A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors。这篇文章从投稿到接收仅仅33天,接收如此之神速,赶紧跟小编一起来学习一下吧。 研究背景: 新泛癌基因的鉴定和...
H.J.J. and Y.L. performed membrane extraction and Western blot analysis; H.J.J., N.L.B. and Y.L. maintained and collected cell lines for LC–MS; H.J.J. performed the HLA-pulldown; Y.L. and X.Q. performed TP53 HCT116 experiments; Y.L. performed immunofluorescence experiments; ...
Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis doi:10.1038/s41698-025-00834-8Medical and Health SciencesOncology and CarcinogenesisDisulfidptosis, a newly discovered cell death mode distinct from other programmed cell death in lung and kidney cancer cells, is ...
That analysis revealed significant differences in the expression of 10 genes in patients aged ≥70years compared with those <70years, of which 7 are involved in androgen signaling and/or DNA repair. CONCLUSIONS: Elderly patients have been underrepresented in genomic sequencing studies. Our data ...