tumor-infiltrating myeloid cells, single-cell transcriptional atlas, pan-cancer analysis, heterogeneity, mast cells, cDCs, TAMs 肿瘤浸润性髓系细胞,单细胞转录图谱,泛癌分析,异质性,肥大细胞,cDCs,TAMs 论文简要 本研究通过全癌分析,构建了肿瘤浸润性髓系细胞的单细胞转录图谱,揭示了肿瘤浸润性髓系细胞的异质...
A pan-cancer spatial single-cell transcriptome atlas.aSchematic depicting the study design. The cancer types included in this pan-cancer study were displayed in the first image on the left, created by Figdraw.bThe number of samples in the pan-cancer analysis of scRNA-seq and ST.cPie chart ...
Here, we perform pan-cancer analysis on 226 samples across 10 solid cancer types to profile the TME at single-cell resolution, illustrating the commonalities/plasticity of heterogenous CAFs. Activation trajectory of the major CAF types is divided into three states, exhibiting distinct interactions ...
Cultured cell lines are the workhorse of cancer research, but the extent to which they recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here we used multiplexed single-cell RNA-seq to profile 198 cancer cell lines from 22 cancer types. We identified 12 expression...
Pan-cancerSingle-cell sequencingImmunotherapyGlycolysisBladder cancerGlycolysis.Sig correlated with immunotherapy response and showed predictive performance across pan-cancer datasets.Hub-Glycolysis.Sig exhibited varying interactions with the immune microenvironment based on cancer type.In bladder cancer, higher ...
RESEARCH ARTICLE SUMMARY◥CANCER IMMUNOLOGYPan-cancer single cell landscapeof tumor-infiltrating T cellsLiangtao Zheng†, Shishang Qin†, Wen Si†, Anqiang Wang, Baocai Xing, Ranran Gao, Xianwen Ren,Li Wang, Xiaojiang Wu, Ji Zhang, Nan Wu, Ning Zhang, Hong Zheng, Hanqiang Ouyang, ...
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes 泛癌单细胞解剖揭示表型不同的B细胞亚型 相关领域 生物 细胞 表型 遗传学 癌症 癌症研究 基因 计算生物学 细胞生物学 网址 https://doi.org/10.1016/j.cell.2024.06.038 ...
The PanCancer IO 360™ panel for immuno-oncology and translational researchers provides potentially clinically actionable genes and signatures. Learn more.
Pan-Cancer Single-Nucleus Total RNA Sequencing Using snHH-Seq 说是说snHH-seq,实际上就是M20平台 总体来说,这个数据是用的pan-cancer的forzen sample,虽然不如成年FFPE降解的多,但是一般用普通单细胞的话,还是会碰到一些RNA降解的问题。所以用细胞核RNA的话比较合适。
A joint study by two groups of researchers at Peking University revealed for the first time the “pan-cancer single-cell landscape of tumor-infiltrating T cells”. The study analyzed tumor-infiltrating T cells from patients of 21 cancer types by means of scRNA-seq. Combinin...