为了解释SPT6在Pol II由暂停进入释放中发挥作用的分子机制,Ali Shilatifard及其研究团队通过构建SPT6-AID细胞系并通过一系列高通量测序揭示了SPT6通过招募PAF1C来促进转录的暂停,并将其结果发表在Molecular Cell上。 首先作者构建了SPT6-AID和PAF1-...
图:基于结构鉴定的一种小分子PAF1复合物(PAF1C)抑制剂,其破坏PAF1染色质定位并释放RNA Pol II。根据发表在《科学进展》杂志上的研究,西北医学院的科学家们发现了一种新的化合物,可以为未来的艾滋病毒治疗策略提供信息。目前对艾滋病毒感染者的标准治疗是抗逆转录病毒药物,它可以抑制病毒的复制和传播,但不能治愈...
型号: AX5PAF1-300.0000T 封装: 8-SMD 批号: 23+ 数量: 5000 RoHS: 是 产品种类: 电子元器件 最小工作温度: -50C 最大工作温度: 130C 最小电源电压: 5V 最大电源电压: 7.5V 长度: 3.5mm 宽度: 6.3mm 高度: 1.2mm 价格说明 价格:商品在爱采购的展示标价,具体的成交价格可能因商品参加活动等情况发...
Fig. 1: PAF1C is a UV-induced interactor of CSB. aResults of SILAC-based MS after GFP-CSB pull-down from CS1AN-SV cells. The number of peptides identified and the UV-induced enrichment (ratio H/L) are shown.bVolcano plot depicting the UV-specific enrichment of proteins after pull-do...
ARTICLE Received 25 Nov 2016 | Accepted 25 Apr 2017 | Published 6 Jun 2017 DOI: 10.1038/ncomms15741 OPEN Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex Youwei Xu1, Carrie Bernecky1, Chung-Tien Lee2,3, Kerstin C. Maier1, Bjo¨rn Schwalb1, Dimitry ...
In fact, depletion of PAF1 causes a release of paused RNA Pol II into downstream of pause sites in human cells (Chen et al., 2015). Recruitment of PAF1C to RNA Pol II during the early elongation needs to be tightly regulated, as PAF1 loss causes activation of CDK9-containing SEC, ...
No intrinsic enzymatic activity has been attributed to either Paf1C as a whole or any of its subunits. Rather, it is thought that Paf1C may regulate the activity or localization of enzyme complexes responsible for histone modifications. Mutational studies indicate that the Rtf1 subunit plays a ...
型号:AX7PAF1-1500.0000C 品牌:Abracon 封装:SMD7050_8P 描述: 国内价格 15+98.02287 35+93.64685 库存:50 去购买 型号:AX7PAF1-1500.0000C 品牌:ABRACON 封装:SMD7050_8P 描述: 国内价格 15+66.77861 35+64.10650 库存:50 去购买 型号:AX7PAF1-1500.0000C 品牌:ABRACON 封装:SMD7050_8P 描述:发射器: CMOS ...
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