2007. Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation. EMBO Rep. 8: 858-863.Akanuma T., Koshida S., Kawamura A., Kishimoto Y., Takada S. 2007. Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation . ...
日前,南开大学生命科学学院/药物化学生物学国家重点实验室龙加福教授研究团队在Paf1复合物促进H2B单泛素化的生化机制研究上获得重要进展。近日, PNAS杂志上在线发表这项成果,题为 Biochemical Insights into Paf1 Complex-induced Stimulation of Rad6/Bre1-mediated H2B Monoubiquitination 。 本文发现Paf1复合物通过与泛...
这些研究为PAF1C对转录调控的分子机制提供了新的依据,为探究转录调控和表观遗传的关系提供了新的思路。 值得一提的是,清华大学陈默课题组近期发表在Cell Reports杂志上题为The PAF1 complex promotes 3’ processing of pervasive transcripts的工...
日前，南开大学生命科学学院、药物化学生物学国家重点实验室龙加福教授研究团队在Paf1复合物促进H2B单泛素化的生化机制研究上获得重要进展，介绍该成果的论文《Biochemical Insights into Paf1 Complex-induced Stimulation of Rad6/Bre1-mediated H2B Monoubiquitination》在8月12日的美国国家科学院院刊PNAS杂志上在线发表。...
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell 4, 403–415 (2009) Article CAS Google Scholar Ponnusamy, M. P. et al. RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction ...
The Paf1 complex (Paf1C), which in Saccharomyces cerevisiae is composed of the five subunits Paf1, Ctr9, Cdc73, Rtf1, and Leo1, was originally identified as a protein complex that co-purifies with RNA pol II (2, 3). Although initially implicated in transcription initiation (2, 3, 4...
Through an unbiased large-scale screen of (G4C2)49-expressing Drosophila we identify the CDC73/PAF1 complex (PAF1C), a transcriptional regulator of RNA polymerase II, as a suppressor of G4C2-associated toxicity when knocked-down. Depletion of PAF1C reduces RNA and GR dipeptide production ...
directs 3′ end formation of nonpolyadenylated RNA pol II transcripts, such as snoRNAs.Deletion of Paf1, but not the Set1, Set2, or Dot1 histone methyltransferases, causes accumulation ofsnoRNA transcripts that are extended at their 3′ ends. The Paf1 complex associates with and facilitate...
9月18号,Nature Communicatons在线发表了龙加福课题组的研究论文Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation。该工作报道了人源和酵母源的Paf1/Ctr9亚复合物2.53Å分辨率的原子结构以及相关功能研究。
1) paf1 complex paf1复合体1. Generation and characterization of antibody against paf1 complex in Drosophila melanogaster; 抗果蝇paf1复合体抗体的制备及其特性(英文)2) replication complex 复制复合体 1. Some viral proteins, host proteins and RNA virus composethe viral replication complex, which ...