CSCs分泌的IL-34会在身旁营造一批“泡沫样”TAMs 研究者们在进一步分析中证实,IL-34会通过上调PPAR信号活性,促进TAMs上调细胞表面的跨膜受体CD36表达,而它确实有调控巨噬细胞脂质摄取,使它们向泡沫细胞状态分化的功能[4]。所以总结起来,由CSCs分泌的IL-34实际上导致了TAMs的代谢重编程和极化转变,让它们变成了促癌...
通过重新分析Trp53null肝肿瘤的snRNA-seq数据,我们发现MDMs中Cd36的表达最高,并且KEGG分析显示这些细胞富集了脂肪酸代谢相关通路和PPAR信号通路,这些通路正向调节CD36表达。流式细胞术分析和多重免疫组化染色进一步确认,Trp53null肝肿瘤中的TAMs表现出更高的CD36表达水平。这些结果表明IL-34通过CD36介导的脂肪酸代谢...
1.潜在“first-in-class”的小分子p53再激活剂(reactivator)PC14586的早期临床结果积极,对多癌种均有疗效。 2. PPARα小分子拮抗剂TPST-1120一线治疗无法切除或转移性肝细胞癌(HCC),患者的无进展生存期(PFS)与总生存期(OS)皆...
p53hypertensionpulmonarymiceRationaleHennigs, Jan K.Cao, AiqinLi, Caiyun G.Shi, MinyiMienert, JuliaMiyagawa, KazuyaKorbelin, JakobMarciano, David P.Chen, Pin-, IRoughley, MatthewElliott, Matthew, VHarper, Rebecca L.Bill, Matthew A.Chappell, JamesMoonen, Jan-RenierDiebold, IsabelWang, Lingli...
5 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; 6 Department of Pneumology & Center for Pulmonary Arterial Hypertension Hamburg, 7 II. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Running title: PPARγ-p53 TF...
PPAR: peroxisome proliferator-activated receptor RB: retinoblastoma protein RAR: retinoic acid receptor ROS: reactive oxygen species RXR: retinoid receptor SG: sebaceous gland S6K1: S6 kinase 1 SREBP: sterol regulatory element binding protein
(PPAR)γ, an inducer of sebocyte differentiation. In addition, Blimp1+sebocytes become depleted concomitantly with an increase in cellular senescence, which can be reversed by PPARγ antagonist (BADGE) treatment. Therefore, our results indicate that p53-mediated aging of the skin involves not only...
PPARG Others Human PPARG / Nr1c3 / PPARgamma 杆状病毒-昆虫细胞裂解液 (阳性对照) 结核冷染液shēng huà shì jì容量:1米 兴国鲤尾鳍细胞;XGLRNaseA 25mg/100mg Sigma分装 p53靶蛋白3抗体大鼠Ⅱ型肺泡上皮细胞完全培养基 100mL单道移液器P10shēng huà shì jì容量:5克 C8-D1A细胞,鼠小脑细胞 NCI...
Scale bar, 50 μm Cell Death and Disease Curcumin induces HSC senescence by PPARγ/P53 H Jin et al (H&E), Masson and picro-Sirius red staining showed that the inhibitory effect of curcumin on liver fibrogenesis was remarkably decreased by interrupting P53 in the model (Figure 4a). More...
17 Curcumin promoted the expression of PPARγ and stimulated the activation of PPARγ, which was a precondition for curcumin to inhibit HSC activation.18 The purpose of the present study was to investigate the signal transduction pathways involved in curcumin induction of activated HSC senescence. ...