p53-positive是什么意识健康咨询描述：p53-positive是什么意识？你好：表示p53蛋白阳性!p53蛋对判断肿瘤的...
3. Liz J Hernández Borrero 1, Wafik S El-Deiry, et al. Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556.4. Sandra L Harris, et al. The p53 pathway: positive and negative feedback loops. Oncogene. 2...
[9] Ji L,Xu J,Liu J,et al. Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor beta (TGF-beta) pathway[J]. J Biol Chem,2015,290(18):11729-40. [10] Song H,Hollstein M,Xu Y. p53 gain-of-function cancer mutants induce...
Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24:2899–2908Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.Harris, S. L.; Levine, A. J. The p53 pathway: positive and negative ...
2b). Cleaved caspase 3 positive cells were counted and expressed as the percentage of total cell number. 5 nm and 35 nm sized AgNPs induced caspase 3 activation with the same extent in both osteosarcoma cell lines. Finally, we wanted to prove that the p53-independent caspase 3 ...
(生物谷Bioon.com) 原文出处:Aprea Therapeutics Announces Positive Results from Phase 2 Trial of Eprenetapopt + Azacitidine for Post-Transplant Maintenance Therapy in TP53 Mutant MDS and AML版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经...
Positive IF/ICC detected in A431 cells Recommended dilution ApplicationDilution Western Blot (WB) WB : 1:5000-1:50000 Immunoprecipitation (IP) IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate Immunohistochemistry (IHC) IHC : 1:250-1:1000 Immunofluorescence (IF)/ICC IF/ICC : 1:200...
S. (2012). Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO Journal, 31(3), 576–592. https://doi.org/10.1038/emboj.2011.434 Article CAS PubMed Google Scholar Swatek, K. N., & Komander, D. (2016). Ubiquitin modifications. Cell Research,...
These findings establish a novel feedback circuit between p53 and ISG15-conjugating system for positive regulation of the tumour suppressive function of p53 under DNA damage conditions. The 'genome guardian' p53 has a well-established role in suppressing tumour development after DNA damage. Here the...
b Abnormal staining pattern in PDAC; nuclear accumulation of p53 protein was observed in IHC, which was defined as “Positive” indicating mutated p53. C, Absence of p53 in PDAC, which was also defined as “Positive”. Example of typical immunohistochemical “Positive” and “Negative” staining...