In contrast to wild-type p53 anti-tumor protective activity, mutant p53 proteins have oncogenic action in culture cells [18], and promote metastasis and genomic instability in mice models [19,20]. Mutations of p53 are often alterations in the central DNA-binding domain and several hotspots such...
In the present study, we have investigated the mechanisms by which the restoration of wild-type (wt) p53 functions in p53 mutant cells increases their susceptibility to the cytotoxic action of tumor necrosis factor (TNF). Our data indicate that the resistance of p53mutated cl.1001 cells to ...
discovered that mutant p53, in combination with tumor necrosis factor (TNF), prolongs NF-κB activation, resulting in a chronic inflammatory phenotype and colon cancer growth. These data support a connection between accumulating missense p53 mutations and NF-κB activation in human cancers linked with...
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell 23, 634–646 (2013). CAS PubMed PubMed Central Google Scholar Weisz, L. et al. Mutant p53 enhances nuclear factor κB activation by tumor necrosis factor α in ...
细胞凋亡标志物包括抗细胞凋亡的Bcl-2相关抗凋亡蛋白-1(Bcl-2 associated athanogene 1,BAG1)、细胞FLICE样抑制蛋白(cellular FLICE-Like inhibitory protein, cFLIP)、肿瘤坏死因子受体相关因子2(Tumor necrosis factor receptor-associated factor 2,TRAF2)和X连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protei...
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emer
如IL-6 (Interleukin-6)和TNF-α(Tumor Necrosis Factor-alpha)。
p53mutations occur in ~50% of human cancers and are commonly associated with poor therapy responses and poor patient outcomes [82]. People with Li-Fraumeni syndrome that inherit one mutantp53allele and one WTp53allele have an ~50% likelihood of developing cancer by the age of 35 and a ~90...
p53 stimulates a wide network of signals that act through two major apoptotic pathways: extrinsic pathways and intrinsic pathways. The extrinsic pathway involves engagement of particular "death" receptors that belong to the tumor TNFR (Tumor Necrosis F...
Ferroptosis differs from conventional necrosis, apoptosis, and autophagy in terms of morphology, biochemistry, and genetics. It exerts critical regulatory functions in tumor progression, rendering it potential candidate for cancer treatment [6]. Recent studies have revealed that inhibitory of ferroptosis ...