成立时间:2004-10-22企业经济性质:股份有限公司年营业额:1亿-10亿 经营模式:代理商,生产商,员工人数:101-500注册资金:8666.6668万人民币 公司评价 暂时还没有评价我要评价 该公司其他产品 p53 Antibody价格:价格电议产品详情:温馨提示:优宁维所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也...
1:50-1:200 - 流式细胞分析 (Flow) 1 µL per 1 x 10^6 cells - 免疫沉淀 (IP) 20 µL/1 mg lysate - 产品规格 种属反应 Human 宿主/亚型 Mouse / IgG2a 分类 Monoclonal 类型 Antibody 克隆号 DO-1 抗原 Recombinant full length protein corresponding to Human p53 (N terminal). epitope is...
p53抗体克隆DO1特异性识别氨基酸20-25之间人p53蛋白N-末端的表位。p53是一种肿瘤抑制基因，在各种散发性和家族性癌症中发生突变。并且p53作为核蛋白，介导细胞周期停滞以响应DNA损伤，因此在维持基因组稳定性方面是重要的。最近的结果表明，ATM响应于对SER15的DNA损伤，p53的磷酸化增强，这是一种降低p53阻止细胞生长的...
The paraffin sections from routinely processed samples of 88 breast cancers were immunostained with the monoclonal p53‐antibody DO‐1. After localization and evaluation with a scoring system the sections were destained and stained by the Feulgen method. The nuclei were relocated automatically and ...
V. & Demidov, O. N. Wip1 phosphatase: between p53 and MAPK kinases pathways. Oncotarget 7, 31563–31571 (2016). Article PubMed PubMed Central Google Scholar Han, J. et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat. Cell Biol. ...
TAD mutants promote EGFR interaction with AKT while DBD mutants interfere with SHP1 binding to EGFR How do TAD versus DBD mutants promote EGFR signaling in the cytosol and nucleus respectively? We first considered the mechanism of TAD mutant p53. Since AKT is a mutant p53 interactor enriched amo...
值得注意的是:目前市面上现有的p53免疫组化品种繁多,DO-7、DO-1、PAb1801及E26等都是针对靠近N端表位。如果蛋白被更远端截断导致表达的蛋白失去远端C端表位,就不会产生N端P53抗体的空染色模式。这种突变会导致P53 C端抗体的无效染色模式。是否需要使用C端P53抗体的免疫组化去验证,目前仅见有该类抗体的报道但还...
p53, clone DO1, mouse monoclonal Ab Abcam Cat# ab1101, RRID: AB_297667 p53 (wild type), clone PAb1620, mouse monoclonal Ab Merck Millipore Cat# MABE339 p53 (mutant), clone PAb240, mouse monoclonal Ab Merck Millipore Cat# OP29L-100UG, RRID: AB_10683175 Mouse p53 (wild type), clone...
p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1 The Drosophila seven in absentia (sina) gene is required for R7 photoreceptor cell formation during Drosophila eye development, where it functions within t... SI Matsuzawa - 《Embo Jour...
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