P40 expression in small cell lung cancer: The presence of p40‐positive cells does not always indicate squamous differentiationDiagnosisimmunohistochemistrysmall cell lung cancerTP63 proteinBackgroundSmall cell lung cancer (SCLC) is normally diagnosed with hematoxylin and eosin stains, although some cases ...
positivein93.5% (100/107)and94.4% (101/107)oflungsquamouscellcarcinomas,40Owaspositivein2.5% (3/I19)oflung adenocarcinomas.Thethree400一positiveeaseshadfocalreactivityin1%～5% oftumorcells.incontrast.063showedreactivityin 26% (31/119)oflungadenocarcinomas(1+,20cases,2+,7cases,3+,4cases).The...
of CK5/6and P40detection for lung squamous cell carcinoma were analyzed.Results The positive expression rates of CK5/6and P40in lung squamous cell carcinoma specimen were higher than those in lung adenocarcinoma specimen (P <0.05).There were no significant differences in the sensitivity,positive ...
smallcelllungcancer(NSCLC)andtoexploretheirvalueinthedifferentialdiagnosisoflungSCCandAC.Methods:UsingthetechnologyofimmunohistochemicalSPmethod,theexpressionsofp63,CK5/6andp40weredetectedin100casesspecimensoflungcarcinomaandtheclinicalpathologicalfeaturesofNSCLCwereanalyzedstatistically.Results:Thepositiveex pressionrates...
Results:In 51 cases with non-small cell lung cancer, there were 20 cases with squamous cell carcinoma and 31 cases with adenocarcinoma. The positive expression rates of p63,p40 and CK5/6 in lung squamous cell carcinoma was 100%(20/20), 95%(19/20) and 90%(18/20)respectively ; the ...
7、 the positive rates of ttf-1 and napsina in ac has significant difference with scc (p0.01), all of which were statistically significant.conclusion in small biopsy specimens of non-small cell lung cancer of low differentiation,the combined detection of dsg3,p40,ttf-1 and napsina is of gr...
At variance, p63-HS was significantly higher than p40 in AD (P < .0001) and NE tumors (P = .0156), with positive predictive value being 83% and 95% and overall accuracy being 95% and 99%, respectively. Also, TTF1 was shared by gland-differentiated and NE tumors. MEM cases were ...
For AdCA cases, p40 was negative, p63 was positive in 2 cases (5%) and CK5/6 was negative in 43/46 cases (92%).#For NSCCA, p40 had 89% sensitivity and 100% specificity compared to p63 with 86% sensitivity and 96% specificity and CK5/6 with 100% sensitivity and 96% specificity. ...
(approaching 100%) for squamous cell carcinoma.7–9,11–15 However, the main limita- tion of p63 is low specificity due to its unexpected reactivity in 16–65% of lung adenocarcino- mas.2,9,14,16–18 In the majority of p63-positive adeno- carcinomas, expression is focal, but in a...
p40、CK56、NapsinA联合CT对晚期非小细胞肺癌的分型诊断效能 细胞肺癌疗效及血清肿瘤标志物的影响［Ｊ］．肿瘤基础与临床，２０１８，３１（０６）：５０７－５０９．ＺＨＡＩＬＧ，ＨＵＤＸ．Ａｐａｔｉｎｉｂｃｏｍｂｉｎｅｄｗｉｔｈｐａｃｌｉｔａｘｅｌａｎｄｃａｒｂｏ ｐｌａｔｉｎｉｎｔｈｅｔｒｅａｔｍｅｎｔｏｆ...