结论 在低分化非小细胞肺癌活检小标本中联合检测dsg3、p40、ttf-1、napsina对鳞癌与腺癌的鉴别诊断具有重要意义。关键词:非小细胞肺癌;dsg3;p40;ttf-1;napsina;活组织检查;免疫组化the expression and si 3、gnificance of dsg3,p40,ttf-1,and napsina in non-small cell lung cancer lacking morphological ...
p40、天门冬氨酸蛋白酶、甲状腺转录因子-1在肺鳞癌与腺癌表达敏感性和特异性 仇加高 【摘要】Objective:To study the significant immunohistochemical mark to identifiy squamous cell carcinoma and adenocarcinoma of non-small cell lung cancer. Methods:The expression of p63, p40, CK5/6, TTF-1, CK7 and ...
Immunohistochemically, the tumor cells were at least focally positive for vimentin, TLE-1, SALL4, CK AE1/AE3 and TTF-1, while being negative for CK7, CK20, Napsin-A, SOX-10, p40 and neuroendocrine markers. Both tumors showed... AK Abu-Salah,S Segura,HM Cramer - 《American Journal ...
P40 expression in small cell lung cancer: The presence of p40‐positive cells does not always indicate squamous differentiationDiagnosisimmunohistochemistrysmall cell lung cancerTP63 proteinBackgroundSmall cell lung cancer (SCLC) is normally diagnosed with hematoxylin and eosin stains, although some cases ...
the main limita- tion of p63 is low specificity due to its unexpected reactivity in 16–65% of lung adenocarcino- mas.2,9,14,16–18 In the majority of p63-positive adeno- carcinomas, expression is focal, but in a subset, it is strong and diffuse, approaching the extent typical of ...
At variance, p63-HS was significantly higher than p40 in AD (P < .0001) and NE tumors (P = .0156), with positive predictive value being 83% and 95% and overall accuracy being 95% and 99%, respectively. Also, TTF1 was shared by gland-differentiated and NE tumors. MEM cases were ...
Fig. 1 The expression of CK5/6, p63, p40, CK7, and MUC5AC in a case of poor-differentiated squamous cell carcinoma by IHC. a H&E; b CK5/6 positive staining; c p63 positive staining; d p40 positive staining; e CK7 positive staining; f MUC5AC negative staining (100×) Full size ...
CK7, TTF-1 and NapsinA were more useful and specific in differentiating lung adenocarcinoma. The impaired CD56, TTF-1, Syn and CgA reflects the progression of small cell lung cancer.Ecological restoration