Immunohistochemical analysis showed positive staining for CK (AE1/AE3), TTF-1, and p40, while CK56, CD68, CD45 (LCA), D2-40, and Ki-67 (50%+) were negative, leading to the diagnosis of lung adenocarcinoma. Second-generation sequencing identified mutations in ERBB2 (EXON20.p.Y772-A...
7. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples.[J].Terry J;Leung S;Laskin J;Leslie KO;Gown AM;Ionescu DN,American Journal of Surgical Pathology.2010,第12期 8. P40: A P63 Isoform Useful for ...
Matteo Bulloni 1,6, Giuseppe Pelosi 3,4,7 & Linda Pattini 1,5,7* The transcription factors TTF1/NKX2-1 and ΔNp63/p40 are the counterposed molecular markers associated with the main Non-Small Cell Lung Cancer subtypes: TTF1 for adenocarcinoma, p40 for squamous cell carcin...
Individual sections received either a set volume of primary antibody solution or an equal volume of CAS Block (negative control). Slides were incubated overnight at 4°C in a humidified chamber. Primary antibody solution was removed and sections washed with PBS. All tissue sections, including ...
Senoo M, Tsuchiya I, Matsumura Y et al (2001) Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinoma: expression of ∆Np73 L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51. Br J Cancer 84:1235–...
was found to act in a dominant negative fashion and to be able to suppress p53 transactivation. In contrast to these other variants, we found no evidence of a tumor suppressor function for p40. Instead, we observed p40 gene overexpression in head and neck cancer cell lines and primary lung ...
(COPD), chronic salicylate intoxication, colorectal carcinoma, congestive heart failure, conjunctivitis, contact dermatitis, cor pulmonale, coronary artery disease, Creutzfeldt-Jakob disease, culture negative sepsis, cystic fibrosis, cytokine therapy associated disorders, Dementia pugilistica, demyelinating ...
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this......
[27]Hainaut P, Plymoth A. Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy. Curr Opin Oncol. 2013;25:50–51.10.1097/CCO.0b013e32835b651eSearch in Google ScholarPubMed [28]Avnet S, Baldini N, Brisson L, Pedersen SF, Porporato PE, Sonveau...
Nuclear Factor κB Dominant Negative Genetic Constructs Inhibit X-ray Induction of Cell Adhesion Molecules in the Vascular Endothelium Human umbilical vein endothelial cells (HUVEC) and human microvascular endothelial cells were treated with the NFKB inhibitors ALLN, PDTC, NAC, and MG132... DE Halla...