MKK6-p38α结合的结构基础 撰文丨存中一贯 丝裂原活化蛋白激酶（mitogen-activated protein kinases, MAPKs）是真核生物中保守的一类信号分子，它们能够响应胞外刺激启动级联信号反应，并导致细胞发生分化或者凋亡的各种生理变化。在高等生物中，MAPK p38α能够对辐射、缺氧、渗透性休克、炎症因子以及病毒进行应激反应【1...
蛋白激酶(protein kinases,简称PK),即催化蛋白质磷酸化过程的酶,在生理状态下,蛋白质激酶的构象转变处于一个动态平衡。激酶不同状态,对其底物结合具有不同的影响。因此,探究蛋白激酶的构象转变对于药物设计具有重要的指导作用[1]。 丝裂原活化蛋白激酶(...
Mitogen-activated protein kinases (MAPKs) p38 MAPK Signal transduction via p38α p38 Function in keratinocytes p38α/β-Dependent regulation of keratinocyte function p38δ-Dependent regulation of epidermal keratinocyte differentiation p38δ Regulation of keratinocyte apoptosis p38δ Function in other cell sy...
The regulation of TNF-alpha, a key mediator in the inflammatory process in IBD, is interconnected with mitogen-activated protein kinase pathways. The aim of this study was to characterize the activity and expression of the four p38 subtypes (p38alpha-delta), c-Jun N-terminal kinases (JNKs),...
P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock,andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAP Kinase (MAPK) is the m...
3.Hari SB, et al.Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalyticfunctions of mitogen-activated protein kinases.Chem Biol. 2014 May22;21(5):628-35. 4. Lee JC, et al. Inhibitionof p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000 ...
2.1.6Mitogen-activated protein kinases Mitogen-activatedprotein kinase(MAPK) is a complex interconnected signaling pathway that is frequently involved in the regulation of cell proliferation, differentiation, migration, and apoptosis, immune and stress responses, as well as gene expressi...
RESEARCHARTICLEOpenAccessp38mitogen-activatedproteinkinaseandmitogen-activatedproteinkinase-activatedproteinkinase2(MK2)signalinginatrophicandhypertrophicdenervatedmouseskeletalmuscleKimEvertsson*,Ann-KristinFjällström,MarleneNorrbyandSvenTågerudAbstractBackground:p38mitogen-activatedproteinkinasehasbeenimplicatedinboth...
p38 mitogen-activated protein (MAP) kinases are the serine/threonine protein kinases, which play a vital role in cellular responses to external stress signals. p38 MAP kinase inhibitors have shown anti-inflammatory effects in the preclinical disease models, primarily through inhibition of the expression...
We have shown that stimulation of β-adrenergic receptors (β-AR) by norepinephrine (NE) increases apoptosis in adult rat ventricular myocytes (ARVMs) via a cAMP-dependent mechanism that is antagonized by activation of G i protein. The family of mitogen-activated protein kinases (MAPKs) is inv...