MKK6-p38α结合的结构基础 撰文丨存中一贯 丝裂原活化蛋白激酶（mitogen-activated protein kinases, MAPKs）是真核生物中保守的一类信号分子，它们能够响应胞外刺激启动级联信号反应，并导致细胞发生分化或者凋亡的各种生理变化。在高等生物中，MAPK p38α能够对辐射、缺氧、渗透性休克、炎症因子以及病毒进行应激反应【1...
Mitogen-activated protein kinases (MAPKs) p38 MAPK Signal transduction via p38α p38 Function in keratinocytes p38α/β-Dependent regulation of keratinocyte function p38δ-Dependent regulation of epidermal keratinocyte differentiation p38δ Regulation of keratinocyte apoptosis p38δ Function in other cell sy...
The regulation of TNF-alpha, a key mediator in the inflammatory process in IBD, is interconnected with mitogen-activated protein kinase pathways. The aim of this study was to characterize the activity and expression of the four p38 subtypes (p38alpha-delta), c-Jun N-terminal kinases (JNKs),...
蛋白激酶(protein kinases,简称PK),即催化蛋白质磷酸化过程的酶,在生理状态下,蛋白质激酶的构象转变处于一个动态平衡。激酶不同状态,对其底物结合具有不同的影响。因此,探究蛋白激酶的构象转变对于药物设计具有重要的指导作用[1]。 丝裂原活化蛋白激酶(...
【1】丝裂原活化蛋白激酶(MAPK;【Mitogen‐activated protein kinase】p38、ERK 和 JNK)级联是进化上保守的信号通路,可调节细胞对各种细胞外刺激【 a variety of extracellular stimuli】(如生长因子和白介素)的反应。MAPK p38 被其特...
mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock,andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAP Kinase (MAPK) is the mammalian orthologue of the yeast Hog1p MAP kinase, which...
2.1.6Mitogen-activated protein kinases Mitogen-activatedprotein kinase(MAPK) is a complex interconnected signaling pathway that is frequently involved in the regulation of cell proliferation, differentiation, migration, and apoptosis, immune and stress responses, as well as gene expressi...
3.Hari SB, et al.Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalyticfunctions of mitogen-activated protein kinases.Chem Biol. 2014 May22;21(5):628-35. 4. Lee JC, et al. Inhibitionof p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000 ...
p38MAPK通路的活性调控及其在类风湿性关节炎中的作用OPENACCESS9激酶(mitogen-activatedproteinkinases,MAPKs)是细胞应激传递信息的关键蛋白质,将炎症、环境应力和转录因子连接起来,然后结合 DNA 到达靶基因 [1,2] 。 MAPKs 家族包括JNK/SAPK(c-jun N-terminal or stress- activated protein linases) ,ERKs(...
RESEARCHARTICLEOpenAccessp38mitogen-activatedproteinkinaseandmitogen-activatedproteinkinase-activatedproteinkinase2(MK2)signalinginatrophicandhypertrophicdenervatedmouseskeletalmuscleKimEvertsson*,Ann-KristinFjällström,MarleneNorrbyandSvenTågerudAbstractBackground:p38mitogen-activatedproteinkinasehasbeenimplicatedinboth...