丝裂原活化蛋白激酶（mitogen-activated protein kinases, MAPKs）是真核生物中保守的一类信号分子，它们能够响应胞外刺激启动级联信号反应，并导致细胞发生分化或者凋亡的各种生理变化。在高等生物中，MAPK p38α能够对辐射、缺氧、渗透性休克、炎症因子以及病毒进行应激反应【1】。这些信号传导通过持续的级联蛋白激酶（MAP...
英文名称: p38 mitogen-activated protein kinase/p38MAPK kit 用途: 用于科研实验,不得用于临床 产地: 上海 品牌: 梵态生物 包装规格: 96T 1800元/48T 1200元 标记物: 咨询客服 样本: 血清,血浆,细胞,组织,等相关液体 检测方法: 酶联免疫法 应用: 定量/定性/酶活检测 检测限: 咨询客服 货号...
在一项新的研究中,来自欧洲分子生物学实验室和和日内瓦大学的研究人员提供了关于一种名为p38α的蛋白的重要新见解,其中这种蛋白属于丝裂原活化蛋白激酶(Mitogen Activated Protein Kinase, MAPK)家族,是触发炎症反应的重要细胞“开关”。他们首次获得了p38α被另一种调节蛋白激酶---MKK6---激活后的结构,为开发阻止细...
丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一组能被不同的细胞外刺激,如细胞因子、神经递质、激素、细胞应激及细胞黏附等激活的丝氨酸-苏氨酸蛋白激酶,MAPK是信号从细胞表面传导到细胞核内部的重要传递者。MAPK通路的基本组成是一种从...
BIRB796 与 p38 MAPK 或 JNK1/2 的结合会损害上游激酶 MKK6 或 MKK4 的磷酸化。BIRB796 阻断应激诱导的支架蛋白SAP97 的磷酸化，而 SAP97 是 p38γ 的生理学底物。此外，BIRB796 还抑制 B-Raf，IC50 分别为 83 nM。参考文献 1. Johnson GL, et al. Mitogen-activated proteinkinase pathways mediated ...
In transient transfections of undifferentiated ES cells, the dPRL promoter is activated by 8-bromo-cAMP and the C subunit (C beta) of PKA. This induction as well as the differentiation-dependent activity of the dPRL promoter in transfected decidualized cells are effectively abolished by the co...
1. Johnson GL, et al. Mitogen-activated proteinkinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002 Dec6;298(5600):1911-2. 2. Wagner EF, et al. Signal integration by JNKand p38 MAPK pathways in cancer development. ...
the molecular mechanisms involved are not fully understood. Mitogen-activated protein kinase (MAPK)a families regulate many aspects of the immune response during microbial infections. MAPK phosphatase (MKP)-1 serves as a feedback control mechanism for p38 and JNK MAPK activities via dephosphorylation....
MAPK(Mitogen activated protein kinase),丝裂原活化蛋白激酶,能通过磷酸化核转录因子、细胞骨架蛋白及酶类等方式,参与细胞增殖、分化、转化及凋亡的调节,并与炎症、肿瘤等多种疾病的发生密切相关。 MAPK 家族的信号通路主要包括 ERK(细胞外信号调控的蛋自激酶)、JNK/SAPK(c-Jun N 端激酶/应激激活的蛋白激酶)、p3...
MAPK mitogen-activated protein kinase MEK mitogen-activated protein kinase/extracellular signal-regulated kinase SAPK stress-activated protein kinase Mitogen-activated protein kinases (MAPKs) Intracellular protein kinase signaling cascades integrate incoming signals derived from a myriad of mitogens, growth fac...