p300 gene alterations in intestinal and diffuse types of gastric carcinoma. Gastric Cancer. 2004;7(2):85-90.N. Koshiishi, J.M. Chong, T. Fukasawa, R. Ikeno, Y. Hayashi, N. Funata, H. Nagai, M. Miyaki, Y. Matsumoto, M. Fukayama, p300 gene alterations in intestinal and diffuse ...
Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. 基因名: EP300 别名: KAT3B,RSTS2,p300 基因ID: 2033 Chromosome:(GRCh37) 22 Start: 41487790 End: 41576081 Strand: 1 信号通路: DNA修饰及其它 组蛋白修饰 细胞周期 炎症相关 肿瘤干...
TF/p300的共凝聚使p300在细胞内局部聚集，促进其反式激活反应，实现对p300催化活性的空间特异的激活，进而协助包括Brd4在内的下游共激活因子的招募。在目标基因调控层面，TF/p300的共凝聚可以影响目标基因转录的起始速度、转录爆发的持续时间等定量参数，实现非线性的激活响应。据此，该文提出了一种基于TF/p300共凝聚的...
All EP300/p300 reagents are produced in house and quality controlled, including 1 EP300/p300 Gene, 2 EP300/p300 Protein. All EP300/p300 reagents are ready to use. All EP300/p300 Reagents EP300/p300 Proteins (2) Recombinant EP300/p300 proteins are expressed by Baculovirus-Insect Cells with...
2024年10月15日,复旦大学王纲团队在Cell Discovery在线发表题为“Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs”的研究论文,该研究结果确定了Med23在少突胶质细胞命运决定中的...
PCAF is a p300/CBP-associated factor in mammals, and it is the equivalent of the yeast Gcn5p (general controlled nonrepressed protein), an acetyltransferase working on histones 3, 4 (HAT A) and thus regulating gene expression. p300 functions also as a co-activator of NF-κB. p300 also ...
Entrez Gene ID: (Human) 2033 功能 RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase ...
Inobrodib is a small molecule which disrupts the growth of cancer cells by inhibiting twin gene co-activation factors, p300 and CBP. It binds to the bromodomain of the twin proteins. It is highly selective and does not impact similar pockets on other proteins. Inobrodib displaces p300/CBP ...
为了进一步研究导致METTL1转录上调的分子机制,我们首先通过GENECARD、PROMO和JASPAR网站预测了METTL1的潜在转录因子。三个数据库发现SP1和YY1是共享的(图4A)。鉴于SP1在前列腺癌关键基因转录调控中的重要作用,我们构建了LNCaP-AI和C4-2中SP1稳定...
英文名称: QuantiSir Specific Gene Knockdown Quantification Kit For Epigenetic Regulators - P300 (96 assays) 总访问: 421 国产/进口: 进口 半年访问: 10 产地/品牌: 美国Epigentek 产品类别: 细胞生物学试剂 规格: P-5002-P300-96 最后更新: 2021-2-24 货号: CAS 号: 参考报价: 96次分析 立即...