Blobel G A 2002 CBP and p300: versatile coregulators with important roles in hematopoietic gene expression; J. Leukoc. Biol. 71 545–556Blobel, G. A. 2002. CBP and p300: versatile coregulators with important roles in hematopoietic gene expression. J. Leukoc. Biol. 71:545-556....
[7] Yu D,Liang Y,Kim C,et al. Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma[J]. Nat Commun,2023,14(1):378. [8] Ghosh AK. Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cell...
上海玉博生物科技有限公司 主要致力于“重组人Cbp/p300-反式作用因子 prospec PRO-701”的生产销售。多年的“重组人Cbp/p300-反式作用因子 prospec PRO-701”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询
Inobrodib is a small molecule which disrupts the growth of cancer cells by inhibiting twin gene co-activation factors, p300 and CBP. It binds to the bromodomain of the twin proteins. It is highly selective and does not impact similar pockets on other proteins. Inobrodib displaces p300/CBP ...
肾脏病与透析肾移植杂志 第 31 卷 第 5 期 2022 年 10 月 ·461· p300 / CBP 在肾脏纤维化的作用和机制 王艳哲 吴 明 综述 叶朝阳 审校 摘 要 肾脏纤维化是各种病因引起的慢性肾脏病的主要病理改变,常进展至终末期肾病. 组蛋白乙酰转移 酶( HATs) 介导的表观遗传调控在肾脏纤维化的发生发展中发挥...
p300 and participate in gene transactivation. PCAF is a p300/CBP-associated factor in mammals, and it is the equivalent of the yeast Gcn5p (general controlled nonrepressed protein), an acetyltransferase working on histones 3, 4 (HAT A) and thus regulating gene expression. p300 functions also ...
gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in ...
Although researchers do not know how a reduction in the amount of CBP or p300 protein leads to the specific features of Rubinstein-Taybi syndrome, it is clear that the loss of one copy of the CBP or p300 gene disrupts normal development. Defects in CBP HAT activity appears to cause ...
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with ...
CBP and p300: versatile coregulators with important roles in hematopoietic gene expression 来自 Semantic Scholar 喜欢 0 阅读量: 27 作者: GA Blobel 摘要: Various attempts have been made to standardize and improve the reproducibility of flow cytometric determination of CD34(+) hematopoietic progenitor ...